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Chemical Compound Review

CHEMBL1593     3-[amino-[bis(2- chloroethyl)amino]phosphor...

Synonyms: AG-F-21072, AC1Q6SYU, CTK1C3648, AR-1F4851, AC1L32O7, ...
 
 
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Disease relevance of C07645

 

High impact information on C07645

 

Biological context of C07645

 

Anatomical context of C07645

 

Associations of C07645 with other chemical compounds

 

Gene context of C07645

 

Analytical, diagnostic and therapeutic context of C07645

References

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  2. Effect of stereochemistry on the oxidative metabolism of the cyclophosphamide metabolite aldophosphamide. Habib, A.D., Boal, J.H., Hilton, J., Nguyen, T., Chang, Y.H., Ludeman, S.M. Biochem. Pharmacol. (1995) [Pubmed]
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  4. Proton-mediated liberation of aldophosphamide from a nontoxic prodrug: a strategy for tumor-selective activation of cytocidal drugs. Tietze, L.F., Neumann, M., Möllers, T., Fischer, R., Glüsenkamp, K.H., Rajewsky, M.F., Jähde, E. Cancer Res. (1989) [Pubmed]
  5. The effects of acetaldophosphamide, a novel stable aldophosphamide analogue, on normal human and leukemic progenitor cells in vitro: implications for use in bone marrow purging. Beran, M., Andersson, B.S., Wang, Y., McCredie, K.B., Farquhar, D. Cancer Res. (1988) [Pubmed]
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  7. Cyclophosphamide and 4-Hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving high-dose cyclophosphamide chemotherapy. Anderson, L.W., Chen, T.L., Colvin, O.M., Grochow, L.B., Collins, J.M., Kennedy, M.J., Strong, J.M. Clin. Cancer Res. (1996) [Pubmed]
  8. Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs. Bunting, K.D., Webb, M., Giorgianni, F., Galipeau, J., Blakley, R.L., Townsend, A.J., Sorrentino, B.P. Hum. Gene Ther. (1997) [Pubmed]
  9. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Dockham, P.A., Lee, M.O., Sladek, N.E. Biochem. Pharmacol. (1992) [Pubmed]
  10. Enhanced expressions of glucose-6-phosphate dehydrogenase and cytosolic aldehyde dehydrogenase and elevation of reduced glutathione level in cyclophosphamide-resistant human leukemia cells. Tsukamoto, N., Chen, J., Yoshida, A. Blood Cells Mol. Dis. (1998) [Pubmed]
  11. Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy. Boal, J.H., Ludeman, S.M., Ho, C.K., Engel, J., Niemeyer, U. Arzneimittel-Forschung. (1994) [Pubmed]
  12. Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines. Dockham, P.A., Sreerama, L., Sladek, N.E. Drug Metab. Dispos. (1997) [Pubmed]
  13. Biotransformation of mafosfamide in P388 mice leukemia cells: intracellular 31P-NMR studies. Sonawat, H.M., Leibfritz, D., Engel, J., Hilgard, P. Biochim. Biophys. Acta (1990) [Pubmed]
  14. Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase. Bunting, K.D., Lindahl, R., Townsend, A.J. J. Biol. Chem. (1994) [Pubmed]
  15. Effects of N-substitution on the activation mechanisms of 4-hydroxycyclophosphamide analogues. Kwon, C.H., Borch, R.F. J. Med. Chem. (1989) [Pubmed]
  16. Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3. Giorgianni, F., Bridson, P.K., Sorrentino, B.P., Pohl, J., Blakley, R.L. Biochem. Pharmacol. (2000) [Pubmed]
  17. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Manthey, C.L., Sladek, N.E. Biochem. Pharmacol. (1988) [Pubmed]
  18. NADPH-dependent enzyme-catalyzed reduction of aldophosphamide, the pivotal metabolite of cyclophosphamide. Parekh, H.K., Sladek, N.E. Biochem. Pharmacol. (1993) [Pubmed]
  19. Pharmacokinetics of cyclophosphamide (CP) and 4-OH-CP/aldophosphamide in systemic vasculitis. Belfayol-Pisanté, L., Guillevin, L., Tod, M., Fauvelle, F. Fundamental & clinical pharmacology. (2000) [Pubmed]
 
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