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Gene Review:

Tnfrsf11a - tumor necrosis factor receptor superfamily...

Mus musculus

Synonyms: Ly109, ODFR, OFE, Osteoclast differentiation factor receptor, Rank, ...

Bachmann, M.F. et al., Sonoda, M. et al., Ohazama, A. et al., Matthews, E.J. et al.

Sonoda, Okamoto, Kajiya, Inoue, Honjo, Sumii, Kawarabayashi, Okabe,

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High impact information on Tnfrsf11a

Here we show that CD4(+) T cell responses to viral infection were greatly diminished in CD40-deficient mice by administration of a soluble form of TNF-related activation-induced cytokine receptor (TRANCE-R) to inhibit the function of another TNF family member, TRANCE [1].
Thus, the TRANCE/TRANCE-R interaction provides costimulation required for efficient CD4(+) T cell priming during viral infection in the absence of CD40L/CD40 [1].
Expression of Opg and Rank was observed in both the internal and the external enamel epithelium as well as in the dental papilla mesenchyme [2].
Anion permeability of the DIDS-insensitive Cl(-) current differed from that of the compound Cl(-) current: Rank order of anion permeability of the DIDS-sensitive Cl(-) channels was I(-) = Br(-) > Cl(-) > gluconate(-), whereas that of the DIDS-insensitive Cl(-) channel was I(-) = Br(-) > Cl(-) >> gluconate(-) [3].
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure [4].

Biological context of Tnfrsf11a

Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis [2].

References

TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. Bachmann, M.F., Wong, B.R., Josien, R., Steinman, R.M., Oxenius, A., Choi, Y. J. Exp. Med. (1999) [Pubmed]
Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. Ohazama, A., Courtney, J.M., Sharpe, P.T. J. Dent. Res. (2004) [Pubmed]
Amino acid-permeable anion channels in early mouse embryos and their possible effects on cleavage. Sonoda, M., Okamoto, F., Kajiya, H., Inoue, Y., Honjo, K., Sumii, Y., Kawarabayashi, T., Okabe, K. Biol. Reprod. (2003) [Pubmed]
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure. Matthews, E.J., Spalding, J.W., Tennant, R.W. Environ. Health Perspect. (1993) [Pubmed]

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TNFRSF11A	Bos taurus
TNFRSF11A	Canis lupus familiaris
TNFRSF11A	Gallus gallus
TNFRSF11A	Homo sapiens
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tnfrsf11a	Xenopus (Silurana) tropicalis

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