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Gene Review

TNFRSF11A  -  tumor necrosis factor receptor superfamily...

Homo sapiens

Synonyms: CD265, FEO, LOH18CR1, ODFR, OFE, ...
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Disease relevance of TNFRSF11A

  • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis [1].
  • We identified two heterozygous insertion mutations in exon 1 of TNFRSF11A in affected members of four families with FEO or familial Paget disease of bone (PDB) [1].
  • These data indicate that TNFRSF11A mutations contribute neither to the vast majority of cases of sporadic or familial PDB, nor to the development of osteosarcoma [2].
  • Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank [3].
  • Interestingly, a significant correlation (r = 0.73, p < 0.0001, Spearman Rank test) was noted between MBHR and intensity of bronchoalveolar lavage eosinophilia at 48 hours [4].

Psychiatry related information on TNFRSF11A

  • The author traces the historical background of brief psychotherapy, focusing on the contributions of Freud, Ferenczi, Rank, and Alexander and French, and then presents a synthesis of contemporary views [5].
  • There were no differences between the first two groups with respect to the distribution of PSE symptoms and signs, Schneider's First Rank Symptoms, or severity of psychopathology [6].
  • The cooperative term, which amounts to only about 10% of the total hydrophobic association free energy, was found to increase the strength of hydrophobic association; this finding differs from the results of earlier Monte Carlo studies with the free energy perturbation method of Rank and Baker (1997) [7].
  • Among persons who do not report risk behaviors for HIV infection, men had substantially higher median rates of HIV infection than women (P less than 0.001, Wilcoxon Signed Rank test), and rates were positively correlated with HIV infection rates in IV drug users in the same clinic (Pearson correlation coefficient [r] = 0.8; P less than 0.001) [8].
  • We rated spoken language (Spoken Language Rank, SLR) on a scale from 0 (no language) to 6 (mature grammar) and examined the effects of side of resection/damage, age at surgery/seizure onset, seizure control postsurgery, and etiology on language development [9].

High impact information on TNFRSF11A


Chemical compound and disease context of TNFRSF11A

  • Ionization of the surface constituents of Edwardsiella tarda cells provided efficient surface charges for the intact cells to be separated from the EOF and damaged or lysed cells when the separation was performed in running buffer (3.94 mM Tris, 0.56 mM borate, 0.013 mM EDTA) at pH 10 [14].
  • Among psychoanalysts of all colorations respecting their Freudian orthodoxy, there is a special mystique and nostalgia around the Oedipus complex and paramountcy of the father in a child's mental life; but Otto Rank took a militant, yet reasoned, stand against such patriarchal biases [15].

Biological context of TNFRSF11A


Anatomical context of TNFRSF11A

  • No specific abnormalities of the TNFRSF11A gene were identified in a Pagetic osteosarcoma, the osteosarcoma cell lines, DNA extracted from Pagetic bone lesions, or DNA extracted from peripheral blood in patients with familial or sporadic Paget's disease including several individuals with early onset Paget's disease [2].
  • CONCLUSIONS: The phenotypic similarities between Rank(del8) and mice previously described with a combined insertion and deletion in Rank confirm the role of this receptor in osteoclastogenesis and lymph node development and suggest that some forms of malignant osteopetrosis in humans could result from a similar defect [3].
  • To understand the ODF-mediated signal transduction mechanism in osteoclastogenesis, we molecularly cloned ODFR from a mouse macrophage-like osteoclast progenitor cell line, C7 [18].
  • In coated capillaries where the EOF is suppressed, however, our model predicts a lower plate number in the presence of an initial voltage ramp [19].
  • We found that nonionic surfactants worked best: they lyse the plasma membrane without significantly influencing K(d), k(off), or the EOF [20].

Associations of TNFRSF11A with chemical compounds

  • Mitochondrial respiration was determined using a Rank oxygen polarograph at 37 degrees C in a sucrose and mannitol respiration medium [21].
  • There was a strong positive relationship between MIB-1 and BUDR by Spearman Rank correlation [22].
  • We report an online concentration and separation method for basic proteins using poly(diallyldimethylammonium chloride) (PDDA) solutions in the presence of reversed EOF [23].
  • With zwitterionic additives of the form +NH3-(CH2)n-COO-, the magnitude of the EOF increase is directly related to the number of methylene groups, (n), which ranges from n = 1 to 7 [24].
  • Our developed method effectively utilized the reversed flow from this cathodic EOF as a driving force for sample proteins using permanently uncoated but dynamic SDS-coated PMMA microchips [25].

Other interactions of TNFRSF11A

  • This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2 [26].
  • Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNFalpha, and TNFRSF11A gene loci [17].
  • Our results suggest that differences in the osteoclastogenesis-inducing capacity of TRANCE-R versus other TRAF6-associated receptors may in part stem from a quantitative difference in the TRAF6-mediated signals [27].
  • IL-6 was increased in children after TBI versus controls on all days studied (day 1, 3158.2 +/- 621.8 pg/ml; day 2, 1111.6 +/- 337.0 pg/ml; day 3, 826.7 +/- 193.5 pg/ml vs. 20.6 +/- 5.8 pg/ml, p < 0.0001, Mann-Whitney Rank Sum) [28].
  • Insertion mutations of the TNFRSF11A gene encoding Receptor Activator of NF kappa B (RANK) have recently been found to be responsible for FEO and rare cases of early onset familial Paget's disease [2].

Analytical, diagnostic and therapeutic context of TNFRSF11A

  • Manipulation of the EOF is essential for achieving optimal separations by MEKC [29].
  • This article presents a 3-D mathematical model for Joule heating and its effects on the EOF and electrophoretic transport of solutes in microfluidic channels [30].
  • The microparticle image velocimetry technique was used to measure the velocity profiles of EOF under the influence of Joule heating [30].
  • The high EOF generated by the coatings facilitated the maintenance of a stable spray when coupling to ESI-MS, and a stable CZE current when working with a sheath flow-assisted analyte deposition onto MALDI targets, respectively [31].
  • The new copolymers, due to their low viscosity high sieving capacity and ability to suppress EOF, represent a better alternative to PDMA and are suitable replaceable matrices for capillary and microchip electrophoresis [32].


  1. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Hughes, A.E., Ralston, S.H., Marken, J., Bell, C., MacPherson, H., Wallace, R.G., van Hul, W., Whyte, M.P., Nakatsuka, K., Hovy, L., Anderson, D.M. Nat. Genet. (2000) [Pubmed]
  2. Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. Sparks, A.B., Peterson, S.N., Bell, C., Loftus, B.J., Hocking, L., Cahill, D.P., Frassica, F.J., Streeten, E.A., Levine, M.A., Fraser, C.M., Adams, M.D., Broder, S., Venter, J.C., Kinzler, K.W., Vogelstein, B., Ralston, S.H. Calcif. Tissue Int. (2001) [Pubmed]
  3. Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank. Kapur, R.P., Yao, Z., Iida, M.H., Clarke, C.M., Doggett, B., Xing, L., Boyce, B.F. J. Bone Miner. Res. (2004) [Pubmed]
  4. Late allergic airway response to segmental bronchopulmonary provocation in allergic subjects is related to peripheral blood basophil histamine release. Jarjour, N.N., Sedgwick, J.B., Swensen, C.A., Busse, W.W. J. Allergy Clin. Immunol. (1997) [Pubmed]
  5. Short-term dynamic psychotherapy. Marmor, J. The American journal of psychiatry. (1979) [Pubmed]
  6. The DSM-III concepts of schizophrenic disorder and schizophreniform disorder. A clinical and prognostic evaluation. Makanjuola, R.O., Adedapo, S.A. The British journal of psychiatry : the journal of mental science. (1987) [Pubmed]
  7. Molecular simulation study of cooperativity in hydrophobic association. Czaplewski, C., Rodziewicz-Motowidło, S., Liwo, A., Ripoll, D.R., Wawak, R.J., Scheraga, H.A. Protein Sci. (2000) [Pubmed]
  8. Sentinel surveillance of human immunodeficiency virus infection in sexually transmitted disease clinics in the United States. McCray, E., Onorato, I.M. Sexually transmitted diseases. (1992) [Pubmed]
  9. Spoken language outcomes after hemispherectomy: factoring in etiology. Curtiss, S., de Bode, S., Mathern, G.W. Brain and language. (2001) [Pubmed]
  10. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Wong, B.R., Besser, D., Kim, N., Arron, J.R., Vologodskaia, M., Hanafusa, H., Choi, Y. Mol. Cell (1999) [Pubmed]
  11. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. Fuller, K., Wong, B., Fox, S., Choi, Y., Chambers, T.J. J. Exp. Med. (1998) [Pubmed]
  12. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. Wong, B.R., Josien, R., Lee, S.Y., Sauter, B., Li, H.L., Steinman, R.M., Choi, Y. J. Exp. Med. (1997) [Pubmed]
  13. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. Wong, B.R., Josien, R., Lee, S.Y., Vologodskaia, M., Steinman, R.M., Choi, Y. J. Biol. Chem. (1998) [Pubmed]
  14. Determination of the bacterial pathogen Edwardsiella tarda in fish species by capillary electrophoresis with blue light-emitting diode-induced fluorescence. Yu, L., Yuan, L., Feng, H., Li, S.F. Electrophoresis (2004) [Pubmed]
  15. The mother not the father. Adams, P.L. The Journal of the American Academy of Psychoanalysis. (1987) [Pubmed]
  16. Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis. Johnson-Pais, T.L., Singer, F.R., Bone, H.G., McMurray, C.T., Hansen, M.F., Leach, R.J. J. Bone Miner. Res. (2003) [Pubmed]
  17. Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. Al-Qawasmi, R.A., Hartsfield, J.K., Everett, E.T., Flury, L., Liu, L., Foroud, T.M., Macri, J.V., Roberts, W.E. J. Dent. Res. (2003) [Pubmed]
  18. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., Yasuda, H., Yano, K., Morinaga, T., Higashio, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  19. Joule heating effects on separation efficiency in capillary zone electrophoresis with an initial voltage ramp. Xuan, X., Hu, G., Li, D. Electrophoresis (2006) [Pubmed]
  20. Selection of surfactants for cell lysis in chemical cytometry to study protein-DNA interactions. Pang, Z., Al-Mahrouki, A., Berezovski, M., Krylov, S.N. Electrophoresis (2006) [Pubmed]
  21. Cyclosporine A decreases rat skeletal muscle mitochondrial respiration in vitro. Hokanson, J.F., Mercier, J.G., Brooks, G.A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  22. A comparison of the predictive power for survival in gliomas provided by MIB-1, bromodeoxyuridine and proliferating cell nuclear antigen with histopathologic and clinical parameters. McKeever, P.E., Ross, D.A., Strawderman, M.S., Brunberg, J.A., Greenberg, H.S., Junck, L. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  23. Online concentration and separation of basic proteins using a cationic polyelectrolyte in the presence of reversed electroosmotic flow. Yu, C.J., Tseng, W.L. Electrophoresis (2006) [Pubmed]
  24. Enhancement of electroosmotic flow using zwitterionic additives. MacDonald, A.M., Sheppard, M.A., Lucy, C.A. Electrophoresis (2005) [Pubmed]
  25. Microchip electrophoretic protein separation using electroosmotic flow induced by dynamic sodium dodecyl sulfate-coating of uncoated plastic chips. Nagata, H., Tabuchi, M., Hirano, K., Baba, Y. Electrophoresis (2005) [Pubmed]
  26. Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. Johnson-Pais, T.L., Nellissery, M.J., Ammerman, D.G., Pathmanathan, D., Bhatia, P., Buller, C.L., Leach, R.J., Hansen, M.F. Int. J. Cancer (2003) [Pubmed]
  27. Strength of TRAF6 signalling determines osteoclastogenesis. Kadono, Y., Okada, F., Perchonock, C., Jang, H.D., Lee, S.Y., Kim, N., Choi, Y. EMBO Rep. (2005) [Pubmed]
  28. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. Bell, M.J., Kochanek, P.M., Doughty, L.A., Carcillo, J.A., Adelson, P.D., Clark, R.S., Wisniewski, S.R., Whalen, M.J., DeKosky, S.T. J. Neurotrauma (1997) [Pubmed]
  29. Characterization of the SDS-induced electroosmotic flow in micellar electrokinetic chromatography with cationic polyelectrolyte-coated capillaries. Pranaityte, B., Padarauskas, A. Electrophoresis (2006) [Pubmed]
  30. Assessment of Joule heating and its effects on electroosmotic flow and electrophoretic transport of solutes in microfluidic channels. Tang, G., Yan, D., Yang, C., Gong, H., Chai, J.C., Lam, Y.C. Electrophoresis (2006) [Pubmed]
  31. Capillary zone electrophoresis of glycopeptides under controlled electroosmotic flow conditions coupled to electrospray and matrix-assisted laser desorption/ionization mass spectrometry. Amon, S., Plematl, A., Rizzi, A. Electrophoresis (2006) [Pubmed]
  32. Separation of DNA fragments in hydroxylated poly(dimethylacrylamide) copolymers. Chiari, M., Cretich, M., Consonni, R. Electrophoresis (2002) [Pubmed]
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