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Gene Review:

CES5A - carboxylesterase 5A

Homo sapiens

Synonyms: CAUXIN, CES4C1, CES5, CES7, Carboxylesterase 5A, ...

Miyazaki, M. et al., Miyazaki, M. et al., Suzuki, Y. et al.

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Disease relevance of CES7

Domestic cats exhibit physiological proteinuria due to the excretion of cauxin, a carboxylesterase, into the urine [1].

High impact information on CES7

These data suggest that cauxin and cauxin-like human proteins are categorized as a novel group of carboxylesterase multigene family [2].
Cauxin is a carboxylesterase-like glycoprotein excreted as a major component of cat urine [3].

Analytical, diagnostic and therapeutic context of CES7

Immunohistochemistry confirmed that cauxin expression in the kidney proximal straight tubules was higher in intact males than in castrated males [1].
Urinary cauxin was detectable by Western blotting in cats older than about 3 months, and its excretion increased with age [1].
Daily cauxin excretion decreased immediately after castration [1].

References

Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase. Miyazaki, M., Yamashita, T., Hosokawa, M., Taira, H., Suzuki, A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006) [Pubmed]
Molecular cloning and characterization of a novel carboxylesterase-like protein that is physiologically present at high concentrations in the urine of domestic cats (Felis catus). Miyazaki, M., Kamiie, K., Soeta, S., Taira, H., Yamashita, T. Biochem. J. (2003) [Pubmed]
Structural Characterization of N-Glycans of Cauxin by MALDI-TOF Mass Spectrometry and Nano LC-ESI-Mass Spectrometry. Suzuki, Y., Miyazaki, M., Ito, E., Suzuki, M., Yamashita, T., Taira, H., Suzuki, A. Biosci. Biotechnol. Biochem. (2007) [Pubmed]

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