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Gene Review

Uty  -  ubiquitously transcribed tetratricopeptide...

Mus musculus

Synonyms: Histone demethylase UTY, Hydb, Kdm6c, Male-specific histocompatibility antigen H-YDB, Ubiquitously transcribed TPR protein on the Y chromosome, ...
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Disease relevance of Uty

  • Female mice in which the BCL6b gene has been interrupted have normal primary responses of CD8(+) T cells to infection with vaccinia expressing the H-Y epitope, Uty, but Uty-specific, BCL6b(-/-), memory CD8(+) T cells have diminished recall proliferative responses to this epitope in vitro [1].

High impact information on Uty

  • Here we describe a novel mouse Y chromosome gene which we call Uty (ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome) [2].
  • A further two, Smcy and Uty , are ubiquitously expressed and their X homologues escape X-inactivation [3].
  • Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11 [4].
  • We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein [4].
  • Injection of female C57BL/6 mice with immature female bone marrow-derived dendritic cells (BMDC) pulsed with a single immunodominant HY(Db) Uty peptide, WMHHNMDLI, induces prolonged survival of syngeneic male skin grafts [5].

Biological context of Uty

  • Tolerance induced by HY(Db) Uty peptide pretreatment is not characterized by clonal deletion: long-term tolerant mice maintain circulating HY(Db) Uty tetramer(+) T cells which expand following exposure to male cells in vivo or in vitro [5].


  1. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Manders, P.M., Hunter, P.J., Telaranta, A.I., Carr, J.M., Marshall, J.L., Carrasco, M., Murakami, Y., Palmowski, M.J., Cerundolo, V., Kaech, S.M., Ahmed, R., Fearon, D.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Greenfield, A., Scott, D., Pennisi, D., Ehrmann, I., Ellis, P., Cooper, L., Simpson, E., Koopman, P. Nat. Genet. (1996) [Pubmed]
  3. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Ehrmann, I.E., Ellis, P.S., Mazeyrat, S., Duthie, S., Brockdorff, N., Mattei, M.G., Gavin, M.A., Affara, N.A., Brown, G.M., Simpson, E., Mitchell, M.J., Scott, D.M. Hum. Mol. Genet. (1998) [Pubmed]
  4. The UTX gene escapes X inactivation in mice and humans. Greenfield, A., Carrel, L., Pennisi, D., Philippe, C., Quaderi, N., Siggers, P., Steiner, K., Tam, P.P., Monaco, A.P., Willard, H.F., Koopman, P. Hum. Mol. Genet. (1998) [Pubmed]
  5. HY peptides modulate transplantation responses to skin allografts. James, E., Scott, D., Chai, J.G., Millrain, M., Chandler, P., Simpson, E. Int. Immunol. (2002) [Pubmed]
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