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Gene Review

Kdm5d  -  lysine (K)-specific demethylase 5D

Mus musculus

Synonyms: H-Y, HY, Histocompatibility Y antigen, Histone demethylase JARID1D, Hya, ...
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Disease relevance of Jarid1d


High impact information on Jarid1d

  • In mice, H-Y antigen comprises at least four distinct epitopes, each recognized by a specific T lymphocyte clone [6].
  • It has recently been shown that one of these epitopes, H-YKk, is a peptide encoded by the Y-linked Smcy gene, presented at the cell surface with the H-2Kk major histocompatibility complex (MHC) molecule [6].
  • Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome [6].
  • We have recently identified Smcy, a ubiquitously expressed gene, in this region and its X-chromosome homologue, Smcx [7].
  • The male-specific transplantation antigen, H-Y, causes rejection of male tissue grafts by genotypically identical female mice and contributes to the rejection of human leukocyte antigen-matched male organ grafts by human females [7].

Biological context of Jarid1d

  • The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties [8].
  • T cells detect several distinct H-Y epitopes, and these are probably peptides, derived from intracellular proteins, that are presented at the cell surface with major histocompatibility complex (MHC) molecules [7].
  • With the object of cloning Hya and Spy, we initiated chromosome walking in the delta Sxrb DNA [9].
  • Smcy transgene does not rescue spermatogenesis in sex-reversed mice [10].
  • The Smcy transgene was ubiquitously expressed in all organs and tissues tested in male and female carriers [10].

Anatomical context of Jarid1d

  • Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome [11].
  • To produce cells carrying deletions, cytotoxic T lymphocytes (CTLs) specific for H-Y antigens were cocultured with a lymphoblastoid cell line derived from a mouse carrying the portion of the short arm defined by the Sxra translocation on the distal end of its X chromosome [12].
  • Variable spread of X inactivation affecting the expression of different epitopes of the Hya gene product in mouse B-cell clones [13].
  • We now report that bm12 mice generate strong H-Y-specific Tc cells following priming in vivo and restimulation in vitro with male bm12 dendritic cells (DC) [14].
  • These data imply an essential role for Th cells, activated by DC as antigen-presenting cells (APC), in changing H-Y-nonresponder bm12 mice into H-Y responders [14].

Associations of Jarid1d with chemical compounds

  • In contrast, other cell surface alloantigens, such as Thy 1, Ly 1, and H-Y and the serum proteins albumin, C3 and Ig, could not be detected on the surface of lung schistosomula by means of comparable techniques [15].
  • Consistent with this, tolerance induction by HY peptide is abrogated by coadministration of lipopolysaccharide [16].
  • C57BL/6 female mice immunized with male cells were the source of memory T cells, whereas C6 mice transgenic for HY-specific T-cell receptor provided naive T cells [17].
  • Such primed and boosted cells gave a strong secondary CTL response to H-Y but none to H-7 [18].
  • To study the potential involvement of tyrosine phosphorylation in the mechanism of positive selection, we have analyzed the activities of the tyrosine kinases pp56lck and pp59fyn in thymocytes expressing a unique TcR specific for HY antigen+ H-2 Db [19].

Other interactions of Jarid1d

  • In this paper we report the construction of YAC transgenic mice containing different regions of the delta Sxr(b) interval including Zfy1, Ube1y, Smcy, and Eif2s3 [10].
  • In a stock of mice segregating for Sxr', we detected an exceptional XX male that proved positive for H-Y antigen [11].
  • A further two, Smcy and Uty , are ubiquitously expressed and their X homologues escape X-inactivation [20].
  • We investigated these two mice and their existing relatives, using H-2 and H-Y typing methods [21].
  • Two sex-specific cDNAs were isolated, F29 and M17, corresponding to the female-specific Xist gene and the male-specific Smcy gene, respectively [22].

Analytical, diagnostic and therapeutic context of Jarid1d


  1. Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells. Kast, W.M., de Waal, L.P., Melief, C.J. J. Exp. Med. (1984) [Pubmed]
  2. Neonatal tolerance to alloantigens alters major histocompatibility complex-restricted response patterns. Müllbacher, A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  3. Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. Sunday, M.E., Weinberger, J.Z., Wolff, S., Dorf, M.E. Eur. J. Immunol. (1981) [Pubmed]
  4. Separation of thymic education from antigen presenting functions of major histocompatibility complex class I molecules. Simpson, E., Robinson, P.J., Chandler, P., Millrain, M.M., Pircher, H.P., Brändle, D., Tomlinson, P., Antoniou, J., Mellor, A. Immunology (1994) [Pubmed]
  5. Prolonged Hya-disparate skin graft survival in ethanol-consuming mice: correlation with impaired delayed hypersensitivity. Wang, K., Busker-Mannie, A.E., Hoeft, J., Vasquez, K., Miller, S.D., Melvold, R.W., Waltenbaugh, C. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  6. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Greenfield, A., Scott, D., Pennisi, D., Ehrmann, I., Ellis, P., Cooper, L., Simpson, E., Koopman, P. Nat. Genet. (1996) [Pubmed]
  7. Identification of a mouse male-specific transplantation antigen, H-Y. Scott, D.M., Ehrmann, I.E., Ellis, P.S., Bishop, C.E., Agulnik, A.I., Simpson, E., Mitchell, M.J. Nature (1995) [Pubmed]
  8. Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus. Sandstedt, S.A., Tucker, P.K. Mamm. Genome (2006) [Pubmed]
  9. A structural analysis of the Sxr region of the mouse Y chromosome. Mitchell, M.J., Bishop, C.E. Genomics (1992) [Pubmed]
  10. Smcy transgene does not rescue spermatogenesis in sex-reversed mice. Agulnik, A.I., Harrison, W.R., Bishop, C.E. Mamm. Genome (2001) [Pubmed]
  11. Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome. McLaren, A., Simpson, E., Epplen, J.T., Studer, R., Koopman, P., Evans, E.P., Burgoyne, P.S. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  12. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. King, T.R., Christianson, G.J., Mitchell, M.J., Bishop, C.E., Scott, D., Ehrmann, I., Simpson, E., Eicher, E.M., Roopenian, D.C. Genomics (1994) [Pubmed]
  13. Variable spread of X inactivation affecting the expression of different epitopes of the Hya gene product in mouse B-cell clones. Scott, D., McLaren, A., Dyson, J., Simpson, E. Immunogenetics (1991) [Pubmed]
  14. Abolition of specific immune response defect by immunization with dendritic cells. Boog, C.J., Kast, W.M., Timmers, H.T., Boes, J., de Waal, L.P., Melief, C.J. Nature (1985) [Pubmed]
  15. Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni. Sher, A., Hall, B.F., Vadas, M.A. J. Exp. Med. (1978) [Pubmed]
  16. Transplantation tolerance induced by intranasal administration of HY peptides. Chai, J.G., James, E., Dewchand, H., Simpson, E., Scott, D. Blood (2004) [Pubmed]
  17. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Krampera, M., Glennie, S., Dyson, J., Scott, D., Laylor, R., Simpson, E., Dazzi, F. Blood (2003) [Pubmed]
  18. Priming for a cytotoxic response to minor histocompatibility antigens: antigen specificity and failure to demonstrate a carrier effect. Bevan, M.J. J. Immunol. (1977) [Pubmed]
  19. Tyrosine kinase triggering in thymocytes undergoing positive selection. Carrera, A.C., Baker, C., Roberts, T.M., Pardoll, D.M. Eur. J. Immunol. (1992) [Pubmed]
  20. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Ehrmann, I.E., Ellis, P.S., Mazeyrat, S., Duthie, S., Brockdorff, N., Mattei, M.G., Gavin, M.A., Affara, N.A., Brown, G.M., Simpson, E., Mitchell, M.J., Scott, D.M. Hum. Mol. Genet. (1998) [Pubmed]
  21. T-cell and antibody typing of a mouse population segregating for Sxr and H-2 haplotype. Simpson, E., Chandler, P., Tomonari, K., Loveland, B., McLaren, A. Cell. Immunol. (1986) [Pubmed]
  22. Isolation of sex-specific cDNAs from fetal mouse brain using mRNA differential display and representational difference analysis. Eriksson, A., Wahlestedt, C., Nordqvist, K. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  23. Spermatogenic failure in male mice lacking H-Y antigen. Burgoyne, P.S., Levy, E.R., McLaren, A. Nature (1986) [Pubmed]
  24. Accumulation of aberrant Y chromosomes in gamma-ray-induced thymic lymphomas lacking p53. Chou, D., Matsuki, J., Saitou, Y., Kosugi, S.I., Shinbo, T., Gejyo, F., Niwa, O., Kominami, R. Mol. Carcinog. (1999) [Pubmed]
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