Disease relevance of Jarid1d

• Athymic H-2b nude mice received grafts from C57BL/6 (Sendai virus and H-Y antigen cytotoxic T lymphocyte [CTL] responder type), bm1 (H-2Kb mutant, Sendai CTL nonresponder type), or bm12 (H-21-A mutant, H-Y CTL nonresponder type) neonates [1].
• Neonatal tolerance to H-2b abrogates the ability of CBA mice to generate secondary H-Y-immune cytotoxic T cells, but such cell activity to third-party alloantigens and to Bebaru and influenza virus is not impaired [2].
• Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses [3].
• Both GPI-Db and TM-Db can efficiently present H-Y antigen, influenza and lymphocytic choriomeningitis virus (LCMV) peptides to primed cytotoxic, H-2Db-restricted T cells [4].
• Prolonged Hya-disparate skin graft survival in ethanol-consuming mice: correlation with impaired delayed hypersensitivity [5].

High impact information on Jarid1d

• In mice, H-Y antigen comprises at least four distinct epitopes, each recognized by a specific T lymphocyte clone [6].
• It has recently been shown that one of these epitopes, H-YKk, is a peptide encoded by the Y-linked Smcy gene, presented at the cell surface with the H-2Kk major histocompatibility complex (MHC) molecule [6].
• Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome [6].
• We have recently identified Smcy, a ubiquitously expressed gene, in this region and its X-chromosome homologue, Smcx [7].
• The male-specific transplantation antigen, H-Y, causes rejection of male tissue grafts by genotypically identical female mice and contributes to the rejection of human leukocyte antigen-matched male organ grafts by human females [7].

Biological context of Jarid1d

• The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties [8].
• T cells detect several distinct H-Y epitopes, and these are probably peptides, derived from intracellular proteins, that are presented at the cell surface with major histocompatibility complex (MHC) molecules [7].
• With the object of cloning Hya and Spy, we initiated chromosome walking in the delta Sxrb DNA [9].
• Smcy transgene does not rescue spermatogenesis in sex-reversed mice [10].
• The Smcy transgene was ubiquitously expressed in all organs and tissues tested in male and female carriers [10].

Anatomical context of Jarid1d

• Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome [11].
• To produce cells carrying deletions, cytotoxic T lymphocytes (CTLs) specific for H-Y antigens were cocultured with a lymphoblastoid cell line derived from a mouse carrying the portion of the short arm defined by the Sxra translocation on the distal end of its X chromosome [12].
• Variable spread of X inactivation affecting the expression of different epitopes of the Hya gene product in mouse B-cell clones [13].
• We now report that bm12 mice generate strong H-Y-specific Tc cells following priming in vivo and restimulation in vitro with male bm12 dendritic cells (DC) [14].
• These data imply an essential role for Th cells, activated by DC as antigen-presenting cells (APC), in changing H-Y-nonresponder bm12 mice into H-Y responders [14].

Associations of Jarid1d with chemical compounds

• In contrast, other cell surface alloantigens, such as Thy 1, Ly 1, and H-Y and the serum proteins albumin, C3 and Ig, could not be detected on the surface of lung schistosomula by means of comparable techniques [15].
• Consistent with this, tolerance induction by HY peptide is abrogated by coadministration of lipopolysaccharide [16].
• C57BL/6 female mice immunized with male cells were the source of memory T cells, whereas C6 mice transgenic for HY-specific T-cell receptor provided naive T cells [17].
• Such primed and boosted cells gave a strong secondary CTL response to H-Y but none to H-7 [18].
• To study the potential involvement of tyrosine phosphorylation in the mechanism of positive selection, we have analyzed the activities of the tyrosine kinases pp56lck and pp59fyn in thymocytes expressing a unique TcR specific for HY antigen+ H-2 Db [19].

Other interactions of Jarid1d

• In this paper we report the construction of YAC transgenic mice containing different regions of the delta Sxr(b) interval including Zfy1, Ube1y, Smcy, and Eif2s3 [10].
• In a stock of mice segregating for Sxr', we detected an exceptional XX male that proved positive for H-Y antigen [11].
• A further two, Smcy and Uty , are ubiquitously expressed and their X homologues escape X-inactivation [20].
• We investigated these two mice and their existing relatives, using H-2 and H-Y typing methods [21].
• Two sex-specific cDNAs were isolated, F29 and M17, corresponding to the female-specific Xist gene and the male-specific Smcy gene, respectively [22].

Analytical, diagnostic and therapeutic context of Jarid1d

• Identification of a mouse male-specific transplantation antigen, H-Y [7].
• Wachtel and his colleagues proposed that this testis-determining function of the Y is mediated by the male-specific cell-surface antigen H-Y, originally defined by skin grafting [23].
• This attractive hypothesis, which has been widely accepted, was based on the assumption that serological tests using antisera raised against male cells were recognizing H-Y antigen [23].
• Because the Y chromosome contributes little to cellular function, the stability of the Y chromosome in the tumors was assessed by polymerase chain reaction by examining three genes: Smcy and Sry on the short arm and Sts in the pseudoautosomal region of the long arm of the Y chromosome [24].
• Transplantation tolerance induced by intranasal administration of HY peptides [16].

References