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Gene Review

Ttc1  -  tetratricopeptide repeat domain 1

Mus musculus

Synonyms: 4833412C19Rik, C79328, TPR repeat protein 1, TPR1, Tetratricopeptide repeat protein 1
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Disease relevance of Ttc1


Psychiatry related information on Ttc1

  • A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain [2].

High impact information on Ttc1


Biological context of Ttc1


Associations of Ttc1 with chemical compounds


Physical interactions of Ttc1


Other interactions of Ttc1


Analytical, diagnostic and therapeutic context of Ttc1

  • Finally, cotransfection with the C-terminal hsp-interacting protein (CHIP) construct, a TPR-containing ubiquitin ligase that interacts with hsp90, increased PPARalpha's and decreased PPARbeta's ability to regulate PPRE-reporter activity upon ligand activation [19].


  1. Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. Yonemasu, R., Minami, M., Nakatsu, Y., Takeuchi, M., Kuraoka, I., Matsuda, Y., Higashi, Y., Kondoh, H., Tanaka, K. DNA Repair (Amst.) (2005) [Pubmed]
  2. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Taipale, M., Kaminen, N., Nopola-Hemmi, J., Haltia, T., Myllyluoma, B., Lyytinen, H., Muller, K., Kaaranen, M., Lindsberg, P.J., Hannula-Jouppi, K., Kere, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Greenfield, A., Scott, D., Pennisi, D., Ehrmann, I., Ellis, P., Cooper, L., Simpson, E., Koopman, P. Nat. Genet. (1996) [Pubmed]
  4. Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK). Tang, N.M., Korth, M.J., Gale, M., Wambach, M., Der, S.D., Bandyopadhyay, S.K., Williams, B.R., Katze, M.G. Mol. Cell. Biol. (1999) [Pubmed]
  5. The UTX gene escapes X inactivation in mice and humans. Greenfield, A., Carrel, L., Pennisi, D., Philippe, C., Quaderi, N., Siggers, P., Steiner, K., Tam, P.P., Monaco, A.P., Willard, H.F., Koopman, P. Hum. Mol. Genet. (1998) [Pubmed]
  6. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. Schrick, J.J., Onuchic, L.F., Reeders, S.T., Korenberg, J., Chen, X.N., Moyer, J.H., Wilkinson, J.E., Woychik, R.P. Hum. Mol. Genet. (1995) [Pubmed]
  7. Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90. Ramsey, A.J., Russell, L.C., Whitt, S.R., Chinkers, M. J. Biol. Chem. (2000) [Pubmed]
  8. Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice. Richards, W.G., Yoder, B.K., Isfort, R.J., Detilleux, P.G., Foster, C., Neilsen, N., Woychik, R.P., Wilkinson, J.E. Am. J. Pathol. (1997) [Pubmed]
  9. The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90. Carrello, A., Ingley, E., Minchin, R.F., Tsai, S., Ratajczak, T. J. Biol. Chem. (1999) [Pubmed]
  10. The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. Hubler, T.R., Denny, W.B., Valentine, D.L., Cheung-Flynn, J., Smith, D.F., Scammell, J.G. Endocrinology (2003) [Pubmed]
  11. P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Gale, M., Blakely, C.M., Darveau, A., Romano, P.R., Korth, M.J., Katze, M.G. Biochemistry (2002) [Pubmed]
  12. Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila. Chen, E.H., Olson, E.N. Dev. Cell (2001) [Pubmed]
  13. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. Chen, M.S., Silverstein, A.M., Pratt, W.B., Chinkers, M. J. Biol. Chem. (1996) [Pubmed]
  14. Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. Becker, W., Kentrup, H., Klumpp, S., Schultz, J.E., Joost, H.G. J. Biol. Chem. (1994) [Pubmed]
  15. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Ma, Q., Whitlock, J.P. J. Biol. Chem. (1997) [Pubmed]
  16. The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains. Smith, J.B., Herschman, H.R. Arch. Biochem. Biophys. (1996) [Pubmed]
  17. Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506. Davies, T.H., Ning, Y.M., Sánchez, E.R. Biochemistry (2005) [Pubmed]
  18. Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain. Galigniana, M.D., Harrell, J.M., Murphy, P.J., Chinkers, M., Radanyi, C., Renoir, J.M., Zhang, M., Pratt, W.B. Biochemistry (2002) [Pubmed]
  19. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Sumanasekera, W.K., Tien, E.S., Davis, J.W., Turpey, R., Perdew, G.H., Vanden Heuvel, J.P. Biochemistry (2003) [Pubmed]
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