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Gene Review

Sohlh1  -  spermatogenesis and oogenesis specific...

Mus musculus

Synonyms: Gm110, LOC227631, NOHLH, Nohlh, Spermatogenesis-and oogenesis-specific basic helix-loop-helix-containing protein 1, ...
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Disease relevance of Sohlh1


High impact information on Sohlh1

  • Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8 [2].
  • Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis [2].
  • In males, Sohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia [1].
  • We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (bHLH) transcription factor) [1].


  1. Sohlh1 is essential for spermatogonial differentiation. Ballow, D., Meistrich, M.L., Matzuk, M., Rajkovic, A. Dev. Biol. (2006) [Pubmed]
  2. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Pangas, S.A., Choi, Y., Ballow, D.J., Zhao, Y., Westphal, H., Matzuk, M.M., Rajkovic, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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