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Gene Review

SLC4A1AP  -  solute carrier family 4 (anion exchanger),...

Homo sapiens

Synonyms: HLC-3, HLC3, Human lung cancer oncogene 3 protein, Kanadaptin, Kidney anion exchanger adapter protein, ...
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Disease relevance of SLC4A1AP


High impact information on SLC4A1AP

  • Kanadaptin is widely expressed in epithelial (kidney, lung, and liver) and non-epithelial cells (brain and skeletal and cardiac muscle) [2].
  • That these effects were specific was implied by the fact that a number of other coexpressed karyophilic GFP-fusion proteins, such as the nucleoporin NUP98 and kanadaptin, did not coaggregate with FLAG-lamin A N195K or R386K [3].
  • Trafficking of kAE1 from its site of synthesis in the endoplasmic reticulum to the plasma membrane was unaffected by co-expression of human kanadaptin [1].
  • Kanadaptin was co-localized with kAE1 in intracellular membranes but not at the plasma membrane in alpha-intercalated cells of rabbit kidney [1].
  • The role of the different NLSs is examined in transfection studies using plasmids encoding full-length kanadaptin with or without green fluorescent protein (GFP) as a fusion tag, as well as truncation derivatives thereof [4].

Biological context of SLC4A1AP


Anatomical context of SLC4A1AP


Analytical, diagnostic and therapeutic context of SLC4A1AP


  1. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. Kittanakom, S., Keskanokwong, T., Akkarapatumwong, V., Yenchitsomanus, P.T., Reithmeier, R.A. Mol. Membr. Biol. (2004) [Pubmed]
  2. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. Chen, J., Vijayakumar, S., Li, X., Al-Awqati, Q. J. Biol. Chem. (1998) [Pubmed]
  3. Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates. Hübner, S., Eam, J.E., Hübner, A., Jans, D.A. Exp. Cell Res. (2006) [Pubmed]
  4. Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin. Hübner, S., Jans, D.A., Xiao, C.Y., John, A.P., Drenckhahn, D. Biochem. J. (2002) [Pubmed]
  5. Mitochondrial and nuclear localization of kanadaptin. Hübner, S., Bahr, C., Gössmann, H., Efthymiadis, A., Drenckhahn, D. Eur. J. Cell Biol. (2003) [Pubmed]
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