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Gene Review:

SV2C - synaptic vesicle glycoprotein 2C

Homo sapiens

Synonyms: KIAA1054, Synaptic vesicle glycoprotein 2C

Janz, R. et al., Janz, R. et al., Lambeng, N. et al., Lynch, B.A. et al.

Lynch, Lambeng, Nocka, Kensel-Hammes, Bajjalieh, Matagne, Fuks, Lambeng, Grossmann, Chatelain, Fuks,

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High impact information on SV2C

No binding was observed to the related isoforms SV2B and SV2C [1].
We describe a novel synaptic vesicle protein called SVOP that is distantly related to the synaptic vesicle proteins SV2A, SV2B, and SV2C (20-22% sequence identity) [2].
Our data suggest that closely related members of a synaptic vesicle protein family can either have very general (SV2A) or restricted distributions (SV2C), possibly in order to allow specialization in the regulation of the expression or of the function of these abundant synaptic vesicle proteins [3].
SV2C was undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex [3].
High levels of SV2C were found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem and the olfactory bulb [3].

Physical interactions of SV2C

The two other isoforms SV2B and SV2C were found to be co-immunoprecipitated with SV2A [4].

References

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Lynch, B.A., Lambeng, N., Nocka, K., Kensel-Hammes, P., Bajjalieh, S.M., Matagne, A., Fuks, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles. Janz, R., Hofmann, K., Südhof, T.C. J. Neurosci. (1998) [Pubmed]
SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family. Janz, R., Südhof, T.C. Neuroscience (1999) [Pubmed]
Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties. Lambeng, N., Grossmann, M., Chatelain, P., Fuks, B. Neurosci. Lett. (2006) [Pubmed]

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SV2C	Bos taurus
LOC488943	Canis lupus familiaris
sv2c	Danio rerio
SV2C	Gallus gallus
SV2C	Macaca mulatta
Sv2c	Mus musculus
SV2C	Pan troglodytes
Sv2c	Rattus norvegicus
sv2c	Xenopus (Silurana) tropicalis

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