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Gene Review

SV2A  -  synaptic vesicle glycoprotein 2A

Homo sapiens

Synonyms: KIAA0736, PSEC0174, SV2, Synaptic vesicle glycoprotein 2A
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Disease relevance of SV2A


High impact information on SV2A


Chemical compound and disease context of SV2A [5].


Biological context of SV2A

  • SV2A and SV2B have been shown to be involved in the regulation of synaptic vesicle exocytosis [6].
  • It cannot be explained by putative binding of [3H]ucb 30889 to SV2B or C isoforms but may reflect different patterns of SV2A glycosylation or the formation of SV2A oligomers [7].
  • Detailed time course analyses showed that an early moderate increase developed within 6 h, preceding a substantial up-regulation of HSP70 after 4 days; an early reduction of syntaxin I in the first 24 h; a delayed reduction of synaptotagmin I after 4 days; and a biphasic change in SV2 [1].
  • Two distinct cDNAs that appear to encode proteins in the synaptic vesicle-2 (SV2) family were identified as expressed sequence tags from a Ctenocephalides felis hindgut and Malpighian tubule (HMT) cDNA library [8]. [9].

Anatomical context of SV2A


Associations of SV2A with chemical compounds

  • Competition experiments were performed to determine the affinities for SV2A of a variety of compounds including levetiracetam, some of its analogues and other molecules known to interact with levetiracetam binding sites in rat brain such as bemegride, pentylenetetrazol and chlordiazepoxide [7].
  • Electrophysiological studies of spontaneous inhibitory neurotransmission in the CA3 region of the hippocampus revealed that loss of SV2A leads to a reduction in action potential-dependent gamma-aminobutyric acid (GABA)ergic neurotransmission [10].
  • N-dodecyl-beta-D-maltoside (DDM) was the best detergent at achieving a high percentage of SV2A solubilization and at maintaining the binding characteristics of a tritiated form of a more potent analogue of LEV, [3H]ucb 30889 ((2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide) [11].
  • Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein common to all synaptic and endocrine vesicles [10].
  • Molecular cloning of a cDNA encoding synaptic vesicle protein 2 (SV2) revealed that it is homologous to a family of proton cotransporters from bacteria and fungi and to a related family of glucose transporters found in mammals [12].

Other interactions of SV2A

  • Our data suggest that closely related members of a synaptic vesicle protein family can either have very general (SV2A) or restricted distributions (SV2C), possibly in order to allow specialization in the regulation of the expression or of the function of these abundant synaptic vesicle proteins [13].
  • The distributions of SV2 and synaptophysin, two synaptic vesicle integral membrane proteins, generally followed the distribution of synaptic vesicles, which were typically evenly distributed under control conditions and had a notable depletion in zone III after stimulation [14].

Analytical, diagnostic and therapeutic context of SV2A


  1. Chronic hypoxia stress-induced differential modulation of heat-shock protein 70 and presynaptic proteins. Fei, G., Guo, C., Sun, H.S., Feng, Z.P. J. Neurochem. (2007) [Pubmed]
  2. Synaptic vesicle protein 2, A new neuroendocrine cell marker. Portela-Gomes, G.M., Lukinius, A., Grimelius, L. Am. J. Pathol. (2000) [Pubmed]
  3. Expression of synaptic vesicle protein 2 (SV2) in neuroendocrine tumours of the gastrointestinal tract and pancreas. Jakobsen, A.M., Ahlman, H., Wängberg, B., Kölby, L., Bengtsson, M., Nilsson, O. J. Pathol. (2002) [Pubmed]
  4. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Lynch, B.A., Lambeng, N., Nocka, K., Kensel-Hammes, P., Bajjalieh, S.M., Matagne, A., Fuks, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer. Yousef, G.M., White, N.M., Kurlender, L., Michael, I., Memari, N., Robb, J.D., Katsaros, D., Stephan, C., Jung, K., Diamandis, E.P. Tumour Biol. (2004) [Pubmed]
  6. SV2B regulates synaptotagmin 1 by direct interaction. Lazzell, D.R., Belizaire, R., Thakur, P., Sherry, D.M., Janz, R. J. Biol. Chem. (2004) [Pubmed]
  7. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Gillard, M., Chatelain, P., Fuks, B. Eur. J. Pharmacol. (2006) [Pubmed]
  8. Identification of two cDNAs encoding synaptic vesicle protein 2 (SV2)-like proteins from epithelial tissues in the cat flea, Ctenocephalides felis. Walmsley, S.J., Gaines, P.J. Insect Mol. Biol. (2004) [Pubmed]
  9. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Lau, Y.F., Kan, Y.W. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  10. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Crowder, K.M., Gunther, J.M., Jones, T.A., Hale, B.D., Zhang, H.Z., Peterson, M.R., Scheller, R.H., Chavkin, C., Bajjalieh, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties. Lambeng, N., Grossmann, M., Chatelain, P., Fuks, B. Neurosci. Lett. (2006) [Pubmed]
  12. Brain contains two forms of synaptic vesicle protein 2. Bajjalieh, S.M., Peterson, K., Linial, M., Scheller, R.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  13. SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family. Janz, R., Südhof, T.C. Neuroscience (1999) [Pubmed]
  14. Activity-related redistribution of presynaptic proteins at the active zone. Tao-Cheng, J.H. Neuroscience (2006) [Pubmed]
  15. Control of neurotransmitter release by an internal gel matrix in synaptic vesicles. Reigada, D., Díez-Pérez, I., Gorostiza, P., Verdaguer, A., Gómez de Aranda, I., Pineda, O., Vilarrasa, J., Marsal, J., Blasi, J., Aleu, J., Solsona, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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