Disease relevance of SV2B

• Northern analysis revealed that three additional genes, ASCL1, INA, and SV2B are expressed in LuCaP 49 but not in various prostate cancer cell lines or xenografts [1].
• The decrease of SV2B mRNA was already detected before the onset of proteinuria in PAN nephropathy [2].

High impact information on SV2B

• No binding was observed to the related isoforms SV2B and SV2C [3].
• While both forms of SV2 are expressed in all brain regions, SV2B is expressed at highest levels in the cortex and hippocampus, whereas the highest level of expression of SV2A is in subcortical regions [4].
• Notably, only 3 genes (ETV5, DUSP6, and KIAA0735) are uniquely induced in mutant ras-containing cells [5].
• These results suggest that SV2B is a functional molecule of podocyte, and SV2B may play a role in the expression and proper localization of CD2AP [2].
• Dual-labeling immunofluorescence studies with glomerular cell markers demonstrated that SV2B is expressed in glomerular visceral epithelial cells (podocytes) [2].

Biological context of SV2B

• SV2A and SV2B have been shown to be involved in the regulation of synaptic vesicle exocytosis [6].
• It cannot be explained by putative binding of [3H]ucb 30889 to SV2B or C isoforms but may reflect different patterns of SV2A glycosylation or the formation of SV2A oligomers [7].

Anatomical context of SV2B

• The expression of SV2B is detected also in cultured podocyte and in human kidney section as podocytic pattern [2].

Associations of SV2B with chemical compounds

• The mRNA expression of SV2B clearly is altered not only in PAN nephropathy but also in another proteinuric state that is caused by an antibody against nephrin, a functional molecule of the slit diaphragm [2].

Other interactions of SV2B

• ASCL1, INA, and SV2B are potential molecular markers for small cell NE tumors and NE cells of the prostate [1].

Analytical, diagnostic and therapeutic context of SV2B

• The expression of SV2B was detected in glomerular lysate with Western blot analysis [2].
• The decreased intensity in SV2B staining was already detected before the peak of proteinuria in both models with immunofluorescence study [2].

References