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Gene Review

NMNAT2  -  nicotinamide nucleotide adenylyltransferase 2

Homo sapiens

Synonyms: C1orf15, KIAA0479, NMN adenylyltransferase 2, NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, ...
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Disease relevance of NMNAT2

  • Sections of pancreas from insulinoma patients showed strong expression of hNMNAT-2 protein in the insulin-producing tumour cells, whereas acinar cells exhibited relatively low expression of hNMNAT-2 protein [1].

High impact information on NMNAT2


Biological context of NMNAT2


Analytical, diagnostic and therapeutic context of NMNAT2

  • Northern blot analysis revealed highly restricted expression of hNMNAT-2 to brain, heart and muscle tissues, which contrasts with the wide tissue expression of hNMNAT-1; different regions of the brain exhibited differential expression of hNMNAT-2 [1].


  1. Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas. Yalowitz, J.A., Xiao, S., Biju, M.P., Antony, A.C., Cummings, O.W., Deeg, M.A., Jayaram, H.N. Biochem. J. (2004) [Pubmed]
  2. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. Berger, F., Lau, C., Dahlmann, M., Ziegler, M. J. Biol. Chem. (2005) [Pubmed]
  3. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H. J. Biol. Chem. (2003) [Pubmed]
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