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Gene Review

Gckr  -  glucokinase regulatory protein

Mus musculus

Synonyms: GKRP, Glucokinase regulator, Glucokinase regulatory protein
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High impact information on Gckr


Biological context of Gckr


Other interactions of Gckr

  • These data suggest both a regulatory and a stabilizing role for GKRP in maintaining adequate glucokinase in the liver [2].

Analytical, diagnostic and therapeutic context of Gckr


  1. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Farrelly, D., Brown, K.S., Tieman, A., Ren, J., Lira, S.A., Hagan, D., Gregg, R., Mookhtiar, K.A., Hariharan, N. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Characterization of glucokinase regulatory protein-deficient mice. Grimsby, J., Coffey, J.W., Dvorozniak, M.T., Magram, J., Li, G., Matschinsky, F.M., Shiota, C., Kaur, S., Magnuson, M.A., Grippo, J.F. J. Biol. Chem. (2000) [Pubmed]
  3. The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Wightman, P.J., Hayward, B.E., Bonthron, D.T. Mamm. Genome (1997) [Pubmed]
  4. Molecular targeting of pancreatic disorders. Tamada, K., Wang, X.P., Brunicardi, F.C. World journal of surgery. (2005) [Pubmed]
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