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Gene Review

Gckr  -  glucokinase (hexokinase 4) regulator

Rattus norvegicus

Synonyms: Glucokinase regulator, Glucokinase regulatory protein
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Disease relevance of Gckr

  • Random peptide phage display library screening for binding partners of GRP allowed the identification of an asparagine-leucine consensus motif [1].
  • Conditional expression of the glucokinase regulatory protein in insulinoma cells, under control of the reverse tetracycline-dependent transactivator, was used to investigate whether expression of this protein de novo would alter the intracellular distribution of glucokinase [2].
  • Here we describe the structure of full-length (2.2 kb) cDNA for human GCKR, from the hepatoblastoma cell line HepG2 [3].

High impact information on Gckr


Biological context of Gckr


Anatomical context of Gckr


Associations of Gckr with chemical compounds


Regulatory relationships of Gckr


Analytical, diagnostic and therapeutic context of Gckr


  1. Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. Baltrusch, S., Francini, F., Lenzen, S., Tiedge, M. Diabetes (2005) [Pubmed]
  2. Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. Bosco, D., Meda, P., Iynedjian, P.B. Biochem. J. (2000) [Pubmed]
  3. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Warner, J.P., Leek, J.P., Intody, S., Markham, A.F., Bonthron, D.T. Mamm. Genome (1995) [Pubmed]
  4. Gene expression of glucokinase regulatory protein in regenerating rat liver. Rosa, J.L., Pérez, J.X., Detheux, M., Van Schaftingen, E., Bartrons, R. Hepatology (1997) [Pubmed]
  5. A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activity. Shiraishi, A., Yamada, Y., Tsuura, Y., Fijimoto, S., Tsukiyama, K., Mukai, E., Toyoda, Y., Miwa, I., Seino, Y. J. Biol. Chem. (2001) [Pubmed]
  6. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. de la Iglesia, N., Mukhtar, M., Seoane, J., Guinovart, J.J., Agius, L. J. Biol. Chem. (2000) [Pubmed]
  7. Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity. Aiston, S., Peak, M., Agius, L. Diabetologia (2000) [Pubmed]
  8. Evidence for glucose and sorbitol-induced nuclear export of glucokinase regulatory protein in hepatocytes. Mukhtar, M., Stubbs, M., Agius, L. FEBS Lett. (1999) [Pubmed]
  9. Glucokinase regulatory protein is associated with mitochondria in hepatocytes. Arden, C., Baltrusch, S., Agius, L. FEBS Lett. (2006) [Pubmed]
  10. Anomeric specificity of human liver and B-cell glucokinase: modulation by the glucokinase regulatory protein. Courtois, P., Bource, F., Sener, A., Malaisse, W.J. Arch. Biochem. Biophys. (2000) [Pubmed]
  11. Regulation of glucokinase by a fructose-1-phosphate-sensitive protein in pancreatic islets. Malaisse, W.J., Malaisse-Lagae, F., Davies, D.R., Vandercammen, A., Van Schaftingen, E. Eur. J. Biochem. (1990) [Pubmed]
  12. Functional glucokinase isoforms are expressed in rat brain. Roncero, I., Alvarez, E., Vázquez, P., Blázquez, E. J. Neurochem. (2000) [Pubmed]
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