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SLC35D2  -  solute carrier family 35 (UDP-GlcNAc/UDP...

Homo sapiens

Synonyms: HFRC, HFRC1, Homolog of Fringe connection protein 1, SQV7-like protein, SQV7L, ...
 
 
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High impact information on SLC35D2

 

Associations of SLC35D2 with chemical compounds

  • Heterologous expression of SLC35D2 protein in yeast indicated that UDP-N-acetylglucosamine is a candidate for the substrate(s) of the transporter [2].
  • SLC35D2 was localized in the Golgi membrane and exhibited around 50% similarity with three nucleotide sugar transporters: human SLC35D1 (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter), fruitfly fringe connection (frc) transporter, and nematode SQV-7 transporter, the latter two being involved in developmental and organogenetic processes [2].
 

Other interactions of SLC35D2

  • The sequence similarity, subcellular localization, and transporting substrate suggest that SLC35D2 is a good candidate for the ortholog of frc transporter, which is involved in the Notch signaling system by providing the fringe N-acetylglucosaminyltransferase with the substrate [2].
 

Analytical, diagnostic and therapeutic context of SLC35D2

References

  1. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. Suda, T., Kamiyama, S., Suzuki, M., Kikuchi, N., Nakayama, K., Narimatsu, H., Jigami, Y., Aoki, T., Nishihara, S. J. Biol. Chem. (2004) [Pubmed]
  2. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida, N., Kuba, T., Aoki, K., Miyatake, S., Kawakita, M., Sanai, Y. Genomics (2005) [Pubmed]
 
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