High impact information on SLC35D2

• In the mammalian cells, HFRC1 transported UDP-GlcNAc and UDP-Glc, but not GDP-Man [1].
• Overexpression of the hfrc1 gene in HCT116 cells modulated the cell surface heparan sulfate expression status [1].
• We identified a novel human nucleotide-sugar transporter gene, hfrc1, which is homologous to Drosophila melanogaster fringe connection, Caenorhabditis elegans sqv-7, and human UGTrel7 [1].
• HFRC1 was localized within the Golgi apparatus following its transient expression in HCT116 cells [1].
• The gene SLC35D2 maps to chromosome 9q22.33 [2].

Associations of SLC35D2 with chemical compounds

• Heterologous expression of SLC35D2 protein in yeast indicated that UDP-N-acetylglucosamine is a candidate for the substrate(s) of the transporter [2].
• SLC35D2 was localized in the Golgi membrane and exhibited around 50% similarity with three nucleotide sugar transporters: human SLC35D1 (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter), fruitfly fringe connection (frc) transporter, and nematode SQV-7 transporter, the latter two being involved in developmental and organogenetic processes [2].

Other interactions of SLC35D2

• The sequence similarity, subcellular localization, and transporting substrate suggest that SLC35D2 is a good candidate for the ortholog of frc transporter, which is involved in the Notch signaling system by providing the fringe N-acetylglucosaminyltransferase with the substrate [2].

Analytical, diagnostic and therapeutic context of SLC35D2

• We report the molecular cloning of SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family [2].
• Northern blot analysis revealed the SLC35D2 mRNA as a single major band corresponding to 2.0 kb in length [2].

References