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Gene Review

RFTN1  -  raftlin, lipid raft linker 1

Homo sapiens

Synonyms: Cell migration-inducing gene 2 protein, FLJ23866, KIAA0084, MIG2, PIB10, ...
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Disease relevance of RFTN1

  • Examination of 30 frozen breast tumors supported the finding that MIG2 is overexpressed in a subset of breast cancers [1].

High impact information on RFTN1

  • Disruption of the Raftlin gene in the DT40 B-cell line resulted in a marked reduction in the quantity of lipid raft components, including Lyn and ganglioside GM1, while overexpression of Raftlin increased the content of raft protein [2].
  • Like the Src family kinase, Raftlin is localized exclusively in lipid rafts by fatty acylation of N-terminal Gly2 and Cys3, and is co-localized with BCR before and after BCR stimulation [2].
  • The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction [2].
  • Moreover, BCR-mediated tyrosine phosphorylation and calcium mobilization were impaired by the lack of Raftlin and actually potentiated by overexpression of Raftlin [2].
  • Although all 21 normal tissues from reduction mammoplasty showed immunoreactivity for MIG2, ranging from weak (62%) to strong (24%), only half of the 34 formalin-fixed breast tumors showed immunoreactivity for MIG2 [1].

Anatomical context of RFTN1

  • Using real-time reverse transcription-PCR, we found that mitogen-inducible gene 2 (MIG2) is expressed at a 17-fold higher level in TMX2-28 cells than in nonaggressive MCF-7 cells and that MIG2 mRNA levels are low in the nontumorigenic human mammary epithelial cell line, 184 [1].

Analytical, diagnostic and therapeutic context of RFTN1


  1. Use of an Aggressive MCF-7 Cell Line Variant, TMX2-28, to Study Cell Invasion in Breast Cancer. Gozgit, J.M., Pentecost, B.T., Marconi, S.A., Otis, C.N., Wu, C., Arcaro, K.F. Mol. Cancer Res. (2006) [Pubmed]
  2. The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction. Saeki, K., Miura, Y., Aki, D., Kurosaki, T., Yoshimura, A. EMBO J. (2003) [Pubmed]
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