Disease relevance of ARC

• Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21(ras), mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent [1].

High impact information on ARC

• Moreover, activity-regulated cytoskeleton-associated gene (Arc), an immediate early gene, is found to be a downstream effector of the BDNF signaling cascade [2].
• Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC) [3].
• In this study, the signal transduction pathway coupling mAChR activation to induction of the activity-regulated cytoskeleton-associated gene (ARC) was examined [3].
• Trafficking of the latter protein is controlled by insulin and insulin receptor function also acting on activity-regulated cytoskeleton-associated gene expression, which induces biochemical stimuli involved in synaptic activity and plasticity [4].
• We examined the effect of insulin on the expression of the activity-regulated cytoskeleton-associated gene (ARC), an effector immediate early gene with a proposed role in memory formation [1].

Biological context of ARC

• Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy [5].
• Here, we tested the hypothesis that genetic variation in the human homolog of the <<<<activity-regulated cytoskeleton-associated gene>>>> (ARC) contributes to the etiology of common IGE disorders [5].
• This review presents the gene expression and alternative splicing of CaMKII during neural differentiation, molecular constituents of PSD, and regulation of CaMKII by activity-regulated cytoskeleton-associated protein (Arc) mainly developed in our study [6].

Anatomical context of ARC

• A local protein synthesis at dendritic spines (ie the activity regulated cytoskeleton associated protein, Arc) probably acts as a signal for plastic modulatory activities in synapses operative in neural group interactions [7].
• The immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is strongly induced and transported to dendritic processes after LTP induction in the dentate gyrus in live rats [8].

References