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Arc  -  activity-regulated cytoskeleton-associated...

Rattus norvegicus

Synonyms: ARC/ARG3.1, Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein, Arg3.1
 
 
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Disease relevance of Arc

 

High impact information on Arc

  • Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles [10].
  • These results demonstrate that NMDA receptor activation is required for the targeting of Arc mRNA to active synapses [11].
  • AMPA receptor antagonists (CNQX) blocked targeting of Arc mRNA in a small region, and mGluR antagonists (MCPG) did not affect localization [11].
  • Newly synthesized Arc protein also accumulates in the portion of the dendrite that had been synaptically activated [12].
  • Here, we report that high frequency activation of the perforant path projections to the dentate gyrus causes newly synthesized mRNA for the immediate-early gene (IEG) Arc to localize selectively in activated dendritic segments [12].
  • The consolidation of long-term potentiation (LTP) in the dentate gyrus requires a period of sustained Arc protein synthesis [13]
  • Arc protein synthesis during LTP consolidation is required for cofilin phosphorylation and enhanced formation of filamentous actin within the termination zone of the medial perforant path input to the dentate gyrus [13].
  • Sustained synthesis of Arc during LTP consolidation is mediated by sustained BDNF-TrkB signaling to MAP kinase interacting kinase (MNK1). MNK controls translation in mechanistically distinct early and late stages [14][15]
 

Biological context of Arc

  • Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA [5].
  • Antidepressant drug treatment induces Arc gene expression in the rat brain [16].
  • Up-regulation of Arc expression may be part of the process by which antidepressant drugs achieve long-term changes in synaptic function in the brain [16].
  • Electron microscopic immunocytochemical methods were used to determine the localization, subcellular distribution and expression of activity-regulated cytoskeletal protein (Arc/Arg3.1) in dentate gyrus after unilateral induction of long-term potentiation (LTP) in the perforant pathway of anaesthetized rats [17].
  • The purpose of the present study is to examine the fidelity of Arc mRNA translation and the temporal dynamics of behaviorally induced Arc protein expression after rats explore a novel environment [7].
 

Anatomical context of Arc

 

Associations of Arc with chemical compounds

 

Regulatory relationships of Arc

  • Sated rats were assessed for food consumption in the presence of a cue that was paired previously with food (CS+), or in the presence of another cue that was never paired with food (CS-), in two consecutive tests temporally arranged for activation of the effector IEGs Arc (activity-regulated cytoskeletal protein) and Homer 1a [22].
  • Local infusion of the transcription inhibitor actinomycin D (ACD) 1 hr before or immediately before BDNF infusion inhibited BDNF-LTP and upregulation of Arc protein expression [23].
  • Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex [24].
  • We examined the function of Arc by introducing Arc cDNA into neuroblastoma cells expressing CaM kinase II [4].
 

Other interactions of Arc

  • The contrasting patterns of Arc expression evoked by cocaine and amphetamine parallel those of c-Fos, JunB, FRA, and NGFI-A expression induced by these two psychomotor stimulants [21].
  • Zif268, Arc and Homer can be modulated in CA1 pyramidal cells approximately twofold after electroshock-induced maximal seizure, which demonstrates potential responsiveness to electrical stimuli [25].
  • Single-cell transcriptional analysis of Arc after whole-cell patch-clamp recordings indicated that increased gene expression correlated with enhancement of synaptic transmission by BDNF [26].
  • Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration [20].
  • Mating behavior induces differential Arc expression in the main and accessory olfactory bulbs of adult rats [27].
 

Analytical, diagnostic and therapeutic context of Arc

References

  1. Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain. Berger, U.V., Lu, X.C., Liu, W., Tang, Z., Slusher, B.S., Hediger, M.A. J. Neurochem. (2003) [Pubmed]
  2. Effect of 5-HT depletion by MDMA on hyperthermia and Arc mRNA induction in rat brain. Beveridge, T.J., Mechan, A.O., Sprakes, M., Pei, Q., Zetterstrom, T.S., Green, A.R., Elliott, J.M. Psychopharmacology (Berl.) (2004) [Pubmed]
  3. Activation of Arc gene, a dendritic immediate early gene, by middle cerebral artery occlusion in rat brain. Kunizuka, H., Kinouchi, H., Arai, S., Izaki, K., Mikawa, S., Kamii, H., Sugawara, T., Suzuki, A., Mizoi, K., Yoshimoto, T. Neuroreport (1999) [Pubmed]
  4. Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase II. Donai, H., Sugiura, H., Ara, D., Yoshimura, Y., Yamagata, K., Yamauchi, T. Neurosci. Res. (2003) [Pubmed]
  5. Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. Ons, S., Martí, O., Armario, A. J. Neurochem. (2004) [Pubmed]
  6. Exposure to lead elevates induction of zif268 and Arc mRNA in rats after electroconvulsive shock: the involvement of protein kinase C. Kim, K.A., Chakraborti, T., Goldstein, G., Johnston, M., Bressler, J. J. Neurosci. Res. (2002) [Pubmed]
  7. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. Ramírez-Amaya, V., Vazdarjanova, A., Mikhael, D., Rosi, S., Worley, P.F., Barnes, C.A. J. Neurosci. (2005) [Pubmed]
  8. Spatio-temporal activation of cyclic AMP response element-binding protein, activity-regulated cytoskeletal-associated protein and brain-derived nerve growth factor: a mechanism for pontine-wave generator activation-dependent two-way active-avoidance memory processing in the rat. Ulloor, J., Datta, S. J. Neurochem. (2005) [Pubmed]
  9. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Rosi, S., Vazdarjanova, A., Ramirez-Amaya, V., Worley, P.F., Barnes, C.A., Wenk, G.L. Neuroscience (2006) [Pubmed]
  10. Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Guzowski, J.F., McNaughton, B.L., Barnes, C.A., Worley, P.F. Nat. Neurosci. (1999) [Pubmed]
  11. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Steward, O., Worley, P.F. Neuron (2001) [Pubmed]
  12. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Steward, O., Wallace, C.S., Lyford, G.L., Worley, P.F. Neuron (1998) [Pubmed]
  13. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. Messaoudi, E., Kanhema, T., Soulé, J., Tiron, A., Dagyte, G., da Silva, B., Bramham, C.R. J. Neurosci. (2007) [Pubmed]
  14. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Panja, D., Kenney, J.W., D'Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., Bramham, C.R. Cell. Rep. (2014) [Pubmed]
  15. Novel translational control in Arc-dependent long term potentiation consolidation in vivo. Panja, D., Dagyte, G., Bidinosti, M., Wibrand, K., Kristiansen, A.M., Sonenberg, N., Bramham, C.R. J. Biol. Chem. (2009) [Pubmed]
  16. Antidepressant drug treatment induces Arc gene expression in the rat brain. Pei, Q., Zetterström, T.S., Sprakes, M., Tordera, R., Sharp, T. Neuroscience (2003) [Pubmed]
  17. Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. Rodríguez, J.J., Davies, H.A., Silva, A.T., De Souza, I.E., Peddie, C.J., Colyer, F.M., Lancashire, C.L., Fine, A., Errington, M.L., Bliss, T.V., Stewart, M.G. Eur. J. Neurosci. (2005) [Pubmed]
  18. Arc interacts with microtubules/microtubule-associated protein 2 and attenuates microtubule-associated protein 2 immunoreactivity in the dendrites. Fujimoto, T., Tanaka, H., Kumamaru, E., Okamura, K., Miki, N. J. Neurosci. Res. (2004) [Pubmed]
  19. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Lyford, G.L., Yamagata, K., Kaufmann, W.E., Barnes, C.A., Sanders, L.K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Lanahan, A.A., Worley, P.F. Neuron (1995) [Pubmed]
  20. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Castro, E., Tordera, R.M., Hughes, Z.A., Pei, Q., Sharp, T. J. Neurochem. (2003) [Pubmed]
  21. The activity-regulated cytoskeletal-associated protein arc is expressed in different striosome-matrix patterns following exposure to amphetamine and cocaine. Tan, A., Moratalla, R., Lyford, G.L., Worley, P., Graybiel, A.M. J. Neurochem. (2000) [Pubmed]
  22. Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating. Petrovich, G.D., Holland, P.C., Gallagher, M. J. Neurosci. (2005) [Pubmed]
  23. Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. Messaoudi, E., Ying, S.W., Kanhema, T., Croll, S.D., Bramham, C.R. J. Neurosci. (2002) [Pubmed]
  24. Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex. Pei, Q., Tordera, R., Sprakes, M., Sharp, T. Neuropharmacology (2004) [Pubmed]
  25. Subfield-specific immediate early gene expression associated with hippocampal long-term potentiation in vivo. French, P.J., O'Connor, V., Jones, M.W., Davis, S., Errington, M.L., Voss, K., Truchet, B., Wotjak, C., Stean, T., Doyère, V., Maroun, M., Laroche, S., Bliss, T.V. Eur. J. Neurosci. (2001) [Pubmed]
  26. Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity. Alder, J., Thakker-Varia, S., Bangasser, D.A., Kuroiwa, M., Plummer, M.R., Shors, T.J., Black, I.B. J. Neurosci. (2003) [Pubmed]
  27. Mating behavior induces differential Arc expression in the main and accessory olfactory bulbs of adult rats. Matsuoka, M., Yoshida-Matsuoka, J., Sugiura, H., Yamagata, K., Ichikawa, M., Norita, M. Neurosci. Lett. (2002) [Pubmed]
  28. Activity-regulated cytoskeleton-associated protein Arc is targeted to dendrites and coexpressed with mu-opioid receptors in postnatal rat caudate-putamen nucleus. Wang, H., Pickel, V.M. J. Neurosci. Res. (2004) [Pubmed]
  29. Effects of stress and adrenalectomy on activity-regulated cytoskeleton protein (Arc) gene expression. Mikkelsen, J.D., Larsen, M.H. Neurosci. Lett. (2006) [Pubmed]
 
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