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Chemical Compound Review:

CPD-6 iron; iron(+2) cation; sulfanide

Synonyms: CHEBI:33739, CHEBI:49601, Fe2S2, Fe2 S2, 2Fe-2S, ...

Bandyopadhyay, A.K. et al., Mansy, S.S. et al., Agar, J.N. et al., Brz??ska, K. et al., Layer, G. et al., et al.

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Disease relevance of Fe2 S2

Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU [1].
Iron-sulfur cluster biosynthesis: biochemical characterization of the conformational dynamics of Thermotoga maritima IscU and the relevance for cellular cluster assembly [2].
Controlled Expression and Functional Analysis of Iron-Sulfur Cluster Biosynthetic Components within Azotobacter vinelandii [3].
Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: correlation of the cluster type with enzymatic activity [4].

High impact information on Fe2 S2

Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly [5].
Iron-sulfur cluster N2 of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I) is located on subunit NuoB [6].
Iron-sulfur cluster biogenesis in chloroplasts. Involvement of the scaffold protein CpIscA [7].
This suggests that at low salt the unfolding of ferredoxin starts with the loss of tertiary structure, which leads to the disruption of the [Fe2-S2] center, resulting in the loss of secondary structural elements [8].
Iron-sulfur cluster biosynthesis in both prokaryotic and eukaryotic cells is known to be mediated by two highly conserved proteins, termed IscS and IscU in prokaryotes [9].

Biological context of Fe2 S2

6-kDa protein with a [Fe2-S2] center and is involved in the oxidative decarboxylation of 2-oxoacids [8].
Iron-sulfur cluster proteins participate in the control of gene expression, oxygen/nitrogen sensing, control of labile iron pool and DNA damage recognition and repair [10].

Associations of Fe2 S2 with other chemical compounds

A Possible Role for Iron-Sulfur Cluster N2 in Proton Translocation by the NADH:Ubiquinone Oxidoreductase (Complex I) [11].

Gene context of Fe2 S2

Iron-sulfur cluster reconstitution of spinach chloroplast Rieske protein requires a partially prefolded apoprotein [12].

References

Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU. Layer, G., Ollagnier-de Choudens, S., Sanakis, Y., Fontecave, M. J. Biol. Chem. (2006) [Pubmed]
Iron-sulfur cluster biosynthesis: biochemical characterization of the conformational dynamics of Thermotoga maritima IscU and the relevance for cellular cluster assembly. Mansy, S.S., Wu, S.P., Cowan, J.A. J. Biol. Chem. (2004) [Pubmed]
Controlled Expression and Functional Analysis of Iron-Sulfur Cluster Biosynthetic Components within Azotobacter vinelandii. Johnson, D.C., Unciuleac, M.C., Dean, D.R. J. Bacteriol. (2006) [Pubmed]
Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: correlation of the cluster type with enzymatic activity. Hofmeister, A.E., Albracht, S.P., Buckel, W. FEBS Lett. (1994) [Pubmed]
Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly. Li, K., Tong, W.H., Hughes, R.M., Rouault, T.A. J. Biol. Chem. (2006) [Pubmed]
Iron-sulfur cluster N2 of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I) is located on subunit NuoB. Flemming, D., Schlitt, A., Spehr, V., Bischof, T., Friedrich, T. J. Biol. Chem. (2003) [Pubmed]
Iron-sulfur cluster biogenesis in chloroplasts. Involvement of the scaffold protein CpIscA. Abdel-Ghany, S.E., Ye, H., Garifullina, G.F., Zhang, L., Pilon-Smits, E.A., Pilon, M. Plant Physiol. (2005) [Pubmed]
Salt dependent stability and unfolding of [Fe2-S2] ferredoxin of Halobacterium salinarum: spectroscopic investigations. Bandyopadhyay, A.K., Sonawat, H.M. Biophys. J. (2000) [Pubmed]
IscU as a scaffold for iron-sulfur cluster biosynthesis: sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU. Agar, J.N., Krebs, C., Frazzon, J., Huynh, B.H., Dean, D.R., Johnson, M.K. Biochemistry (2000) [Pubmed]
Iron-sulfur cluster proteins: electron transfer and beyond. Brz??ska, K., Meczy??ska, S., Kruszewski, M. Acta Biochim. Pol. (2006) [Pubmed]
A Possible Role for Iron-Sulfur Cluster N2 in Proton Translocation by the NADH:Ubiquinone Oxidoreductase (Complex I). Flemming, D., Stolpe, S., Schneider, D., Hellwig, P., Friedrich, T. J. Mol. Microbiol. Biotechnol. (2005) [Pubmed]
Iron-sulfur cluster reconstitution of spinach chloroplast Rieske protein requires a partially prefolded apoprotein. Gubernator, B., Króliczewski, J., Kallas, T., Szczepaniak, A. Biochim. Biophys. Acta (2006) [Pubmed]

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