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Gene Review:

POFUT1 - protein O-fucosyltransferase 1

Homo sapiens

Synonyms: DDD2, FUT12, GDP-fucose protein O-fucosyltransferase 1, KIAA0180, O-FUT, ...

Loriol, C. et al., Menzel, O. et al., Wang, Y. et al.

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High impact information on POFUT1

The human gene (POFUT1) is on chromosome 20 between PLAGL2 and KIF3B, near the centromere at 20p11 [1].
The last common ancestor of all analyzed bilaterian species would be predicted to possess polyexonic Pofut genes in their genome [2].
Molecular evolution of protein O-fucosyltransferase genes and splice variants [2].
The enzyme adding fucose to EGF-like repeats, protein O-fucosyltransferase 1 (Pofut1), is a soluble protein located in the lumen of endoplasmic reticulum (ER) [2].
The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development [3].

Biological context of POFUT1

Here, we isolated and characterized C21orf80 (human chromosome 21 open reading frame 80), a potential novel protein O-fucosyltransferase gene that encodes three alternatively spliced transcripts [3].

References

Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. Wang, Y., Shao, L., Shi, S., Harris, R.J., Spellman, M.W., Stanley, P., Haltiwanger, R.S. J. Biol. Chem. (2001) [Pubmed]
Molecular evolution of protein O-fucosyltransferase genes and splice variants. Loriol, C., Dupuy, F., Rampal, R., Dlugosz, M.A., Haltiwanger, R.S., Maftah, A., Germot, A. Glycobiology (2006) [Pubmed]
The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development. Menzel, O., Vellai, T., Takacs-Vellai, K., Reymond, A., Mueller, F., Antonarakis, S.E., Guipponi, M. Genomics (2004) [Pubmed]

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AgaP_AGAP011338	Anopheles gambiae str. PEST
POFUT1	Bos taurus
C15C7.7	Caenorhabditis elegans
POFUT1	Canis lupus familiaris
pofut1	Danio rerio
O-fut1	Drosophila melanogaster
POFUT1	Gallus gallus
Pofut1	Mus musculus
POFUT1	Pan troglodytes
Pofut1	Rattus norvegicus
pofut1	Xenopus (Silurana) tropicalis

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