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Gene Review

Fez1  -  fasciculation and elongation protein zeta...

Mus musculus

Synonyms: Fasciculation and elongation protein zeta-1, UNC-76, UNC76, Zygin I, Zygin-1
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Disease relevance of Fez1

  • By the yeast two-hybrid screening of a rat brain cDNA library with the regulatory domain of protein kinase C zeta (PKCzeta) as a bait, we have cloned a gene coding for a novel PKCzeta-interacting protein homologous to the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth and fasciculation [1].

High impact information on Fez1


Anatomical context of Fez1


  1. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda, S., Nakagawa, N., Tokunaga, C., Tatematsu, K., Tanizawa, K. J. Cell Biol. (1999) [Pubmed]
  2. Fez1 is layer-specifically expressed in the adult mouse neocortex. Inoue, K., Terashima, T., Nishikawa, T., Takumi, T. Eur. J. Neurosci. (2004) [Pubmed]
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