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Gene Review

ZNF346  -  zinc finger protein 346

Homo sapiens

Synonyms: JAZ, Just another zinc finger protein, Zfp346, Zinc finger protein 346
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High impact information on ZNF346

  • Thus, JAZ is a novel negative regulator of cell growth by positively regulating p53 [1].
  • JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity [1].
  • Now, we report that the stress of IL-3 growth factor withdrawal up-regulates JAZ expression in hematopoietic cells in association with p53 activation and induction of cell death [1].
  • We previously identified JAZ as a novel zinc finger (ZF) protein by screening a murine interleukin-3 (IL-3)-dependent NFS/N1.H7 myeloid cell cDNA library [1].
  • JAZ also binds to ILF3, and surprisingly, this interaction is RNA independent, even though it requires the dsRNA binding domains of ILF3 [2].

Biological context of ZNF346


Anatomical context of ZNF346

  • JAZ does not contain a classical nuclear localization signal, and in digitonin-permeabilized cells, nuclear accumulation of JAZ does not require energy or cytosol [2].

Physical interactions of ZNF346

  • We found that JAZ binds to exportin-5 in a Ran-GTP- and dsRNA-dependent manner [2].

Other interactions of ZNF346

  • Together, these data suggest that JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism [2].


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