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Gene Review

PRKD3  -  protein kinase D3

Homo sapiens

Synonyms: EPK2, PKC-NU, PKD3, PRKCN, Protein kinase C nu type, ...
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High impact information on PRKD3

  • Kinase-inactive forms of PKD1, PKD2 and PKD3 localize to the TGN in polarized and non-polarized cells [1].
  • The nuclear import of protein kinase D3 requires its catalytic activity [2].
  • We also found that activation loop phosphorylation of PKD3 did not require its nuclear localization, and it was not sufficient to promote the nuclear import of PKD3 [2].
  • Real time imaging of a photoactivatable green fluorescent protein fused to PKD3 revealed that point mutations that render PKD3 catalytically inactive completely prevented its nuclear import despite its interaction with importin alpha and beta [2].
  • We found that the C-terminal region of PKD3, which contains its catalytic domain, is necessary but not sufficient for its nuclear localization [2].

Biological context of PRKD3

  • Most prominently, adenoviral gene expression of a dominant-negative PKD isoform, PKD3, primarily inhibits basal glucose uptake and, to a lesser extent, insulin-stimulated glucose uptake, whereas overexpression of wild-type PKD3 significantly enhances basal glucose uptake [3].

Anatomical context of PRKD3


Associations of PRKD3 with chemical compounds

  • Moreover, expression of a PKD3-targeted siRNA significantly inhibits basal glucose uptake [3].

Other interactions of PRKD3


  1. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Yeaman, C., Ayala, M.I., Wright, J.R., Bard, F., Bossard, C., Ang, A., Maeda, Y., Seufferlein, T., Mellman, I., Nelson, W.J., Malhotra, V. Nat. Cell Biol. (2004) [Pubmed]
  2. The nuclear import of protein kinase D3 requires its catalytic activity. Rey, O., Papazyan, R., Waldron, R.T., Young, S.H., Lippincott-Schwartz, J., Jacamo, R., Rozengurt, E. J. Biol. Chem. (2006) [Pubmed]
  3. Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes. Chen, J., Lu, G., Wang, Q.J. Mol. Pharmacol. (2005) [Pubmed]
  4. Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists. Rey, O., Yuan, J., Young, S.H., Rozengurt, E. J. Biol. Chem. (2003) [Pubmed]
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