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Gene Review:

FLRT3 - fibronectin leucine rich transmembrane...

Homo sapiens

Synonyms: Fibronectin-like domain-containing leucine-rich transmembrane protein 3, KIAA1469, Leucine-rich repeat transmembrane protein FLRT3, UNQ856/PRO1865

Robinson, M. et al., Lacy, S.E. et al., Böttcher, R.T. et al.

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High impact information on FLRT3

In gain- and loss-of function experiments, FLRT3 and FLRT2 phenocopy FGF signalling in Xenopus laevis [1].
FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth [2].
However, in the adult, we found no evidence for accumulation or reexpression of the FLRT3 protein in damaged axons of the central nervous system [2].
In vitro, the FLRT3 protein was expressed at the cell surface, regulated neurite outgrowth in sensory neurons, but did not exhibit homophilic binding [2].
The protein was then transported into their peripheral and central processes where the FLRT3 protein was localized to presynaptic axon terminals [2].

Anatomical context of FLRT3

We conclude that FLRT3 codes for a putative cell surface receptor implicated in both the development of the nervous system and in the regeneration of the peripheral nervous system (PNS) [2].
FLRT3 was widely expressed in the developing embryo, particularly in the central nervous system and somites [2].
FLRT1 is expressed in kidney and brain, FLRT2 is expressed in pancreas, skeletal muscle, brain, and heart, and FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart [3].

Associations of FLRT3 with chemical compounds

Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins [3].

References

The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Böttcher, R.T., Pollet, N., Delius, H., Niehrs, C. Nat. Cell Biol. (2004) [Pubmed]
FLRT3 is expressed in sensory neurons after peripheral nerve injury and regulates neurite outgrowth. Robinson, M., Parsons Perez, M.C., Tébar, L., Palmer, J., Patel, A., Marks, D., Sheasby, A., De Felipe, C., Coffin, R., Livesey, F.J., Hunt, S.P. Mol. Cell. Neurosci. (2004) [Pubmed]
Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. Lacy, S.E., Bönnemann, C.G., Buzney, E.A., Kunkel, L.M. Genomics (1999) [Pubmed]

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FLRT3	Bos taurus
FLRT3	Canis lupus familiaris
flrt3	Danio rerio
FLRT3	Gallus gallus
FLRT3	Macaca mulatta
Flrt3	Mus musculus
FLRT3	Pan troglodytes
Flrt3	Rattus norvegicus
flrt3	Xenopus (Silurana) tropicalis

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