Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Coro1b - coronin, actin binding protein 1B

Mus musculus

Synonyms: Coronin-1B, Coronin-2, coronin 2

Cai, L. et al., Okumura, M. et al., Di Giovanni, S. et al.

Di Giovanni, Knights, Rao, Yakovlev, Beers, Catania, Avantaggiati, Faden,

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High impact information on Coro1b

We also demonstrate that acetylation of lysine 320 (K320) of p53 is specifically involved in the promotion of neurite outgrowth and in the regulation of the expression of Coronin 1b and Rab13 [1].
Rat2 fibroblasts expressing the Coronin 1B S2A mutant show enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in single cell tracking assays [2].
Pharmacological experiments show that the interaction between Coronin 1B and the Arp2/3 complex is regulated by protein kinase C (PKC) phosphorylation [2].
These data demonstrate that Coronin 1B regulates leading edge dynamics and cell motility in fibroblasts, and that its ability to control motility and interactions with the Arp2/3 complex are regulated by PKC phosphorylation at Ser-2 [2].
Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein [3].

Biological context of Coro1b

The gene for coronin-2 is localized to mouse chromosome 19, 5' of the gene for CD45-associated protein [3].
Furthermore, Coronin 1B phosphorylation is responsible for a significant fraction of the effects of PMA on fibroblast motility [2].

References

The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. Di Giovanni, S., Knights, C.D., Rao, M., Yakovlev, A., Beers, J., Catania, J., Avantaggiati, M.L., Faden, A.I. EMBO J. (2006) [Pubmed]
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. Cai, L., Holoweckyj, N., Schaller, M.D., Bear, J.E. J. Biol. Chem. (2005) [Pubmed]
Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. Okumura, M., Kung, C., Wong, S., Rodgers, M., Thomas, M.L. DNA Cell Biol. (1998) [Pubmed]

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