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Gene Review

Ptprcap  -  protein tyrosine phosphatase, receptor...

Mus musculus

Synonyms: AI605264, CD-45-AP, CD45-AP, CD45-associated protein, LPAP, ...
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Disease relevance of Ptprcap


High impact information on Ptprcap


Biological context of Ptprcap


Anatomical context of Ptprcap

  • However, lymphnodes from LPAP-null mice showed increased cellularity, which could indicate that expression of LPAP might be required to prevent expansion of lymphocytes in particular lymphatic organs rather than potentiating immune responses [8].
  • By subtractive hybridization using single-stranded phagemids with directional inserts, we isolated a mouse cDNA clone, LSM-1, from temperature-sensitive Abelson virus-transformed immature B cells whose differentiation was being induced after the shift from the permissive (35 degrees C) to the non-permissive temperature (39 degrees C) [9].
  • Cells expressing the CD45-associated hematopoietic marker are predominantly present in the mammalian bone marrow (BM), but have recently been shown to also reside in the skeletal muscle and potentially participate in muscle repair [10].
  • The two CD45-AP proteins are identical in their capacity for specific binding to CD45, but employ different mechanisms for endoplasmic reticulum membrane translocation [11].
  • Similar analysis of various types of leukocytes demonstrated that CD45-AP is expressed in T, B, and pre-B cells, but not in plasma cells or cells of the monocyte/macrophage lineage [11].

Associations of Ptprcap with chemical compounds


Physical interactions of Ptprcap

  • In vitro translated CD45-AP bound specifically to CD45 [6].
  • Interestingly, the ability of CD45-AP to interact with Lck in the absence of other lymphoid-specific molecules was proportional to the degree of catalytic activation of p56(lck) [13].

Regulatory relationships of Ptprcap


Other interactions of Ptprcap

  • Therefore, our results support a model in which binding of CD45-AP to inactive CD45 dimers converts them to active monomers [1].

Analytical, diagnostic and therapeutic context of Ptprcap


  1. CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity. Takeda, A., Matsuda, A., Paul, R.M., Yaseen, N.R. Blood (2004) [Pubmed]
  2. Potentiation of insulin-related signal transduction by a novel protein-tyrosine phosphatase inhibitor, Et-3,4-dephostatin, on cultured 3T3-L1 adipocytes. Suzuki, T., Hiroki, A., Watanabe, T., Yamashita, T., Takei, I., Umezawa, K. J. Biol. Chem. (2001) [Pubmed]
  3. Disruption of lymphocyte function and signaling in CD45-associated protein-null mice. Matsuda, A., Motoya, S., Kimura, S., McInnis, R., Maizel, A.L., Takeda, A. J. Exp. Med. (1998) [Pubmed]
  4. Interaction between CD45-AP and protein-tyrosine kinases involved in T cell receptor signaling. Motoya, S., Kitamura, K., Matsuda, A., Maizel, A.L., Yamamoto, H., Takeda, A. J. Biol. Chem. (1999) [Pubmed]
  5. Assignment of the CD45-AP gene to the centromeric end of mouse chromosome 19 and human chromosome 11q13.1-q13.3. Takai, S., Kozak, C.A., Kitamura, K., Takeda, A. Genomics (1996) [Pubmed]
  6. Molecular cloning of the CD45-associated 30-kDa protein. Takeda, A., Maizel, A.L., Kitamura, K., Ohta, T., Kimura, S. J. Biol. Chem. (1994) [Pubmed]
  7. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. Okumura, M., Kung, C., Wong, S., Rodgers, M., Thomas, M.L. DNA Cell Biol. (1998) [Pubmed]
  8. Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Ding, I., Bruyns, E., Li, P., Magada, D., Paskind, M., Rodman, L., Seshadri, T., Alexander, D., Giese, T., Schraven, B. Eur. J. Immunol. (1999) [Pubmed]
  9. Isolation of a cDNA clone encoding a novel membrane protein expressed in lymphocytes. Shimizu, Y., Ogawa, H., Oka, Y., Mizuno, R., Sakoda, S., Kishimoto, T., Sugiyama, H. FEBS Lett. (1994) [Pubmed]
  10. A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. Rosu-Myles, M., Stewart, E., Trowbridge, J., Ito, C.Y., Zandstra, P., Bhatia, M. J. Cell. Sci. (2005) [Pubmed]
  11. CD45-associated protein is a lymphocyte-specific membrane protein expressed in two distinct forms. Kitamura, K., Matsuda, A., Motoya, S., Takeda, A. Eur. J. Immunol. (1997) [Pubmed]
  12. Characterization of the interaction between CD45 and CD45-AP. Kitamura, K., Maiti, A., Ng, D.H., Johnson, P., Maizel, A.L., Takeda, A. J. Biol. Chem. (1995) [Pubmed]
  13. Interactions of CD45-associated protein with the antigen receptor signaling machinery in T-lymphocytes. Veillette, A., Soussou, D., Latour, S., Davidson, D., Gervais, F.G. J. Biol. Chem. (1999) [Pubmed]
  14. The monoclonal antibody CZ-1 identifies a mouse CD45-associated epitope expressed on interleukin-2-responsive cells. Brutkiewicz, R.R., O'Donnell, C.L., Maciaszek, J.W., Welsh, R.M., Vargas-Cortes, M. Eur. J. Immunol. (1993) [Pubmed]
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