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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Colec10  -  collectin sub-family member 10

Mus musculus

Synonyms: CL-L1, Cll1, Collectin liver protein 1, Collectin-10
 
 
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Disease relevance of Colec10

  • Antitumor effects of nonconjugated murine Lym-2 and human-mouse chimeric CLL-1 monoclonal antibodies against various human lymphoma cell lines in vitro and in vivo [1].
 

High impact information on Colec10

  • Chimeric CLL-1 antibody fusion proteins containing granulocyte-macrophage colony-stimulating factor or interleukin-2 with specificity for B-cell malignancies exhibit enhanced effector functions while retaining tumor targeting properties [2].
  • The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q [3].
  • In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac [3].
  • Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos [3].

References

  1. Antitumor effects of nonconjugated murine Lym-2 and human-mouse chimeric CLL-1 monoclonal antibodies against various human lymphoma cell lines in vitro and in vivo. Funakoshi, S., Hirano, A., Beckwith, M., Asai, O., Jorgensen, G., Tian, Z., Hornick, J.L., Hu, P., Khawli, L.A., Epstein, A.L., Longo, D.L., Murphy, W.J. Blood (1997) [Pubmed]
  2. Chimeric CLL-1 antibody fusion proteins containing granulocyte-macrophage colony-stimulating factor or interleukin-2 with specificity for B-cell malignancies exhibit enhanced effector functions while retaining tumor targeting properties. Hornick, J.L., Khawli, L.A., Hu, P., Lynch, M., Anderson, P.M., Epstein, A.L. Blood (1997) [Pubmed]
  3. Molecular cloning of mouse collectin liver 1. Kawai, T., Suzuki, Y., Eda, S., Kase, T., Ohtani, K., Sakai, Y., Keshi, H., Fukuoh, A., Sakamoto, T., Nozaki, M., Copeland, N.G., Jenkins, N.A., Wakamiya, N. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
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