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Gene Review

Abce1  -  ATP-binding cassette, sub-family E (OABP),...

Mus musculus

Synonyms: ATP-binding cassette sub-family E member 1, C79080, Oabp, RLI, RNS41, ...
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High impact information on Abce1

  • Inversely, transfection of the RLI antisense construct was associated with increased RNase L activity, a diminished level of MyoD mRNA, and delayed differentiation [1].
  • The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation [1].
  • Additionally, variations in RNase L activity have been observed during cell growth and differentiation but the significance of the 2-5A/RNase L/RLI pathway in these latter processes is not known [1].
  • Moreover, reticulocyte lysate translated Mu-RLI protein is also able to inhibit 2-5A binding on 2-5A-dependent RNAse-L [2].
  • Northern blot analysis revealed that Mu-RLI cDNA hybridizes with one mRNA of 3.5 kb except for the testis where two mRNA of 3.5 and 2.1 kb, respectively, are detected, suggesting a tissue-specific regulation [2].

Anatomical context of Abce1

  • To determine the roles of RNase L and RLI in muscle differentiation, C2 mouse myoblasts were transfected with sense and antisense RLI cDNA constructs [1].

Regulatory relationships of Abce1


  1. The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation. Bisbal, C., Silhol, M., Laubenthal, H., Kaluza, T., Carnac, G., Milligan, L., Le Roy, F., Salehzada, T. Mol. Cell. Biol. (2000) [Pubmed]
  2. cDNA cloning and expression analysis of the murine ribonuclease L inhibitor. Benoit De Coignac, A., Bisbal, C., Lebleu, B., Salehzada, T. Gene (1998) [Pubmed]
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