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Rnasel  -  ribonuclease L (2', 5'-oligoisoadenylate...

Mus musculus

Synonyms: 2-5A-dependent RNAase, 2-5A-dependent RNase, 2-5A-dependent ribonuclease, E230029I04Rik, RNase L, ...
 
 
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Disease relevance of Rnasel

 

High impact information on Rnasel

 

Biological context of Rnasel

 

Anatomical context of Rnasel

  • Notably, a deficiency in both PKR and RNase L resulted in a decreased ability of type I IFN to inhibit WNV in primary macrophages and cortical neurons [11].
  • Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells [12].
  • The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture [13].
  • Although the permissivity of cells in lymph nodes draining the inoculation site was increased in the absence of PKR/RNase L, systemic dissemination of the virus infection was restricted by an alternative IFN-alpha/beta receptor-dependent mechanism [14].
  • Therefore, RNase L is directly involved in myoblast differentiation, probably through its role in regulating MyoD stability [15].
 

Associations of Rnasel with chemical compounds

 

Regulatory relationships of Rnasel

 

Other interactions of Rnasel

  • Here we report that in mouse embryo fibroblasts that are devoid of the interferon-regulated RNase, RNase-L, the monensin-induced decrease in the half-life of mt-mRNA was reduced [16].
  • Furthermore, our results indicate the existence of an interferon-mediated antipoxvirus pathway that operates independently of PKR, Mx1, or the 2-5A/RNase L system [20].
  • Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs [21].
  • These responses are essentially intact in the absence of PKR and/or RNase L (K. D. Ryman, L. J. White, R. E. Johnston, and W. B. Klimstra, Viral Immunol. 15:53-76, 2002) [12].
  • Here, we investigated the individual and combined contributions of the two best characterized INF-alpha/beta-mediated antiviral pathways to the control of Sindbis virus replication: (1) the coupled 2-5A synthetase/RNase L pathway and (2) the double-stranded RNA-dependent protein kinase (PKR) pathway [14].
 

Analytical, diagnostic and therapeutic context of Rnasel

  • Although mice lacking RNase L showed a higher CNS viral burden and an increased mortality, they were less susceptible than the PKR(-/-) x RL(-/-) mice; thus, we also infer an antiviral role for PKR in the control of WNV infection [11].
  • In Western blot, only the 80-kDa form of RNase L is recognized by these antibodies [22].
  • These purified antibodies were used to localize RNase L in the cytoplasm of intact mouse NIH 3T3 cells by immunofluorescence [22].
  • Phase-contrast microscopy, EM, flow cytometry, and rRNA analyses demonstrated that contrary to MVA, NYVAC infection induces potent apoptosis, a phenomenon dependent on activation of caspases and RNase L [23].
  • Interestingly, Sin85B vaccination did not protect RNase L-/- (a key enzyme in the innate antiviral response) mice while significant protection was detected in RNase L-/- mice immunized with either BCG or a conventional DNA plasmid expressing antigen 85B [24].

References

  1. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. Zhou, A., Paranjape, J.M., Der, S.D., Williams, B.R., Silverman, R.H. Virology (1999) [Pubmed]
  2. Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection. Austin, B.A., James, C., Silverman, R.H., Carr, D.J. J. Immunol. (2005) [Pubmed]
  3. RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection. Flodström-Tullberg, M., Hultcrantz, M., Stotland, A., Maday, A., Tsai, D., Fine, C., Williams, B., Silverman, R., Sarvetnick, N. J. Immunol. (2005) [Pubmed]
  4. RNase L plays a role in the antiviral response to West Nile virus. Scherbik, S.V., Paranjape, J.M., Stockman, B.M., Silverman, R.H., Brinton, M.A. J. Virol. (2006) [Pubmed]
  5. Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Zhou, A., Hassel, B.A., Silverman, R.H. Cell (1993) [Pubmed]
  6. Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. Zhou, A., Paranjape, J., Brown, T.L., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Colmenares, C., Silverman, R.H. EMBO J. (1997) [Pubmed]
  7. Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication. Watling, D., Serafinowska, H.T., Reese, C.B., Kerr, I.M. EMBO J. (1985) [Pubmed]
  8. RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR. Khabar, K.S., Siddiqui, Y.M., al-Zoghaibi, F., al-Haj, L., Dhalla, M., Zhou, A., Dong, B., Whitmore, M., Paranjape, J., Al-Ahdal, M.N., Al-Mohanna, F., Williams, B.R., Silverman, R.H. J. Biol. Chem. (2003) [Pubmed]
  9. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Al-Khatib, K., Williams, B.R., Silverman, R.H., Halford, W., Carr, D.J. Exp. Eye Res. (2005) [Pubmed]
  10. Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-beta. Al-Khatib, K., Williams, B.R., Silverman, R.H., Halford, W.P., Carr, D.J. J. Interferon Cytokine Res. (2002) [Pubmed]
  11. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. Samuel, M.A., Whitby, K., Keller, B.C., Marri, A., Barchet, W., Williams, B.R., Silverman, R.H., Gale, M., Diamond, M.S. J. Virol. (2006) [Pubmed]
  12. Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. Ryman, K.D., Meier, K.C., Nangle, E.M., Ragsdale, S.L., Korneeva, N.L., Rhoads, R.E., MacDonald, M.R., Klimstra, W.B. J. Virol. (2005) [Pubmed]
  13. The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture. Al-khatib, K., Williams, B.R., Silverman, R.H., Halford, W., Carr, D.J. Virology (2003) [Pubmed]
  14. Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis. Ryman, K.D., White, L.J., Johnston, R.E., Klimstra, W.B. Viral Immunol. (2002) [Pubmed]
  15. The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation. Bisbal, C., Silhol, M., Laubenthal, H., Kaluza, T., Carnac, G., Milligan, L., Le Roy, F., Salehzada, T. Mol. Cell. Biol. (2000) [Pubmed]
  16. RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts. Chandrasekaran, K., Mehrabian, Z., Li, X.L., Hassel, B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Yan, W., Ma, L., Stein, P., Pangas, S.A., Burns, K.H., Bai, Y., Schultz, R.M., Matzuk, M.M. Mol. Cell. Biol. (2005) [Pubmed]
  18. 8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities. Kitade, Y., Nakata, Y., Hirota, K., Maki, Y., Pabuccuoglu, A., Torrence, P.F. Nucleic Acids Res. (1991) [Pubmed]
  19. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. Guidotti, L.G., Morris, A., Mendez, H., Koch, R., Silverman, R.H., Williams, B.R., Chisari, F.V. J. Virol. (2002) [Pubmed]
  20. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. Xiang, Y., Condit, R.C., Vijaysri, S., Jacobs, B., Williams, B.R., Silverman, R.H. J. Virol. (2002) [Pubmed]
  21. Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Iordanov, M.S., Wong, J., Bell, J.C., Magun, B.E. Mol. Cell. Biol. (2001) [Pubmed]
  22. Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells. Salehzada, T., Silhol, M., Lebleu, B., Bisbal, C. J. Biol. Chem. (1991) [Pubmed]
  23. Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene. Nájera, J.L., Gómez, C.E., Domingo-Gil, E., Gherardi, M.M., Esteban, M. J. Virol. (2006) [Pubmed]
  24. Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis. Derrick, S.C., Yang, A.L., Morris, S.L. Infect. Immun. (2005) [Pubmed]
 
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