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Gene Review

Grin3a  -  glutamate receptor ionotropic, NMDA3A

Mus musculus

Synonyms: 6430537F04, A830097C19Rik, NMDAR-L, NR3A, mKIAA1973
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High impact information on Grin3a

  • CONCLUSIONS: This sex-specific increase in PPI is consistent with the antagonistic role of the NR3A subunit in NMDA receptor function and with the observation that estrogen modulates NMDA receptor function [1].
  • A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle [1].
  • In the brain, the NR3A subunit is localized primarily in the amygdala, hippocampus, striatum, and cortex [1].
  • NR3A reduces NMDA current in native neurons expressing NR1 and NR2 subunits and forms glycine receptors when expressed with NR1 in the absence of NR2 in both oocyte and mammalian expression systems [1].
  • The expression of NR3A mRNA was restricted to the dentate gyrus and layers IV and V of the neocortex [2].

Associations of Grin3a with chemical compounds

  • Both the NR2 and the NR3 subunits formed homo- and hetero-oligomers only in the presence of the NR1 subunit indicating differential roles of the subunits in NMDA receptor assembly [3].

Other interactions of Grin3a

  • Although NR3A mRNA expression decreases sharply after the second postnatal weeks, NR3B mRNA expression levels in whole brain were constant during postnatal development and into adult [4].


  1. A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Brody, S.A., Nakanishi, N., Tu, S., Lipton, S.A., Geyer, M.A. Biol. Psychiatry (2005) [Pubmed]
  2. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. Bendel, O., Meijer, B., Hurd, Y., von Euler, G. Neurosci. Lett. (2005) [Pubmed]
  3. Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. Schüler, T., Mesic, I., Madry, C., Bartholomäus, I., Laube, B. J. Biol. Chem. (2008) [Pubmed]
  4. Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. Matsuda, K., Kamiya, Y., Matsuda, S., Yuzaki, M. Brain Res. Mol. Brain Res. (2002) [Pubmed]
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