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Grin3b  -  glutamate receptor, ionotropic, NMDA3B

Mus musculus

Synonyms: GluN3B, Glutamate receptor ionotropic, NMDA 3B, N-methyl-D-aspartate receptor subunit NR3B, NMDA receptor 4, NMDAR3B, ...
 
 
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High impact information on Grin3b

  • Interestingly, mRNA of the NR1 subunit, which is required for functional NMDA receptors, displayed a 'V'-shaped change, decreasing with the early postnatal decline of NR2 mRNAs and increasing with the subsequent appearance of NR3B mRNA [1].
  • NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons [1].
  • In the present study, we investigated the effects of co-expression of the NR3B subunit on the anesthetic sensitivities of NMDA receptors for NR1/NR2 channels expressed in Xenopus oocytes [2].
  • Although NR3A mRNA expression decreases sharply after the second postnatal weeks, NR3B mRNA expression levels in whole brain were constant during postnatal development and into adult [3].
  • Important functional domains of glutamate receptors, such as the ligand-binding domain, the channel pore, and the channel gate, are conserved in NR3B [3].
 

Anatomical context of Grin3b

  • NR3B mRNA was expressed highly in pons, midbrain, medulla, and the spinal cord, but at low levels in the forebrain and the cerebellum [3].
  • NR3B shows very restricted expression in somatic motoneurons of the brainstem and spinal cord [4].
  • Here we report that our analysis using an antibody specific for NR3B showed that the NR3B protein is selectively expressed in somatic motor neurons in the brainstem of adult mice [5].
 

Associations of Grin3b with chemical compounds

  • In contrast, NR3B was not involved in the excitatory glycine response in neurons under our test conditions [5].

References

  1. NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons. Fukaya, M., Hayashi, Y., Watanabe, M. Eur. J. Neurosci. (2005) [Pubmed]
  2. The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors. Yamakura, T., Askalany, A.R., Petrenko, A.B., Kohno, T., Baba, H., Sakimura, K. Anesth. Analg. (2005) [Pubmed]
  3. Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. Matsuda, K., Kamiya, Y., Matsuda, S., Yuzaki, M. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  4. Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. Nishi, M., Hinds, H., Lu, H.P., Kawata, M., Hayashi, Y. J. Neurosci. (2001) [Pubmed]
  5. Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors. Matsuda, K., Fletcher, M., Kamiya, Y., Yuzaki, M. J. Neurosci. (2003) [Pubmed]
 
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