Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cyp11b2 - cytochrome P450, family 11, subfamily b,...

Rattus norvegicus

Synonyms: Aldosterone synthase, CYPXIB2, Cp45as, Cyp11b-2, Cyp11b3, ...

Feuillan, P.P. et al., Faroqui, S. et al., Ito, T. et al.

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High impact information on Cyp11b2

CMA enhanced serum aldosterone levels by 54% and increased the expression of aldosterone synthase in the adrenal gland by 134% after 5d of CMA [1].
In situ hybridization studies revealed that cytochrome P-450 ALDO synthetase mRNA was confined to the subcapsular zona glomerulosa, whereas cytochrome P-450 11 beta-hydroxylase mRNA was present only in the zona fasciculata-reticularis [2].
Here, adrenocortical function in 7-day-old Sprague-Dawley rats was studied by measuring the effects of angiotensin II (Ang II) and ACTH on serum aldosterone (ALDO), corticosterone, and cytochrome P-450 ALDO synthetase and 11 beta-hydroxylase messenger RNA (mRNA) levels with and without dexamethasone (DEX) treatment [2].
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes [3].

References

Metabolic acidosis has dual effects on sodium handling by rat kidney. Faroqui, S., Sheriff, S., Amlal, H. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
Regulation of aldosterone in the 7-day-old rat. Feuillan, P.P., Aguilera, G. Endocrinology (1996) [Pubmed]
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Ito, T., Yoshimura, M., Nakamura, S., Nakayama, M., Shimasaki, Y., Harada, E., Mizuno, Y., Yamamuro, M., Harada, M., Saito, Y., Nakao, K., Kurihara, H., Yasue, H., Ogawa, H. Circulation (2003) [Pubmed]

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cyp11c1	Danio rerio
CYP11B1	Homo sapiens
CYP11B1	Macaca mulatta
Cyp11b2	Mus musculus
LOC464437	Pan troglodytes
LOC101731070	Xenopus (Silurana) tropicalis

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