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Gene Review

CYP11B1  -  cytochrome P450, family 11, subfamily B,...

Homo sapiens

Synonyms: CPN1, CYP11B, CYPXIB1, Cytochrome P-450c11, Cytochrome P450 11B1, mitochondrial, ...
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Disease relevance of CYP11B1


Psychiatry related information on CYP11B1

  • The subjects were tested with the following instruments: Event Effect Scale, PTSS-10 Scale, FHI, Brief Eysenck's Personality Inventory, LEAIQ, GHQ-60, General Questionnaire for Accidents [5].

High impact information on CYP11B1


Chemical compound and disease context of CYP11B1


Biological context of CYP11B1


Anatomical context of CYP11B1


Associations of CYP11B1 with chemical compounds


Regulatory relationships of CYP11B1


Other interactions of CYP11B1


Analytical, diagnostic and therapeutic context of CYP11B1


  1. Disorders of steroid 11 beta-hydroxylase isozymes. White, P.C., Curnow, K.M., Pascoe, L. Endocr. Rev. (1994) [Pubmed]
  2. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. Pascoe, L., Curnow, K.M., Slutsker, L., Connell, J.M., Speiser, P.W., New, M.I., White, P.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia. Portrat, S., Mulatero, P., Curnow, K.M., Chaussain, J.L., Morel, Y., Pascoe, L. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  4. A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency. Naiki, Y., Kawamoto, T., Mitsuuchi, Y., Miyahara, K., Toda, K., Orii, T., Imura, H., Shizuta, Y. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  5. Investigation of psychopathological state of patients depending on specific clinical characteristics of physical trauma. Opalic, P., Lesic, A. Panminerva medica. (2002) [Pubmed]
  6. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Lifton, R.P., Dluhy, R.G., Powers, M., Rich, G.M., Gutkin, M., Fallo, F., Gill, J.R., Feld, L., Ganguly, A., Laidlaw, J.C. Nat. Genet. (1992) [Pubmed]
  7. A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin. White, P.C., Dupont, J., New, M.I., Leiberman, E., Hochberg, Z., Rösler, A. J. Clin. Invest. (1991) [Pubmed]
  8. Primary aldosteronism: hypertension with a genetic basis. Gordon, R.D., Klemm, S.A., Tunny, T.J., Stowasser, M. Lancet (1992) [Pubmed]
  9. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme. Curnow, K.M., Mulatero, P., Emeric-Blanchouin, N., Aupetit-Faisant, B., Corvol, P., Pascoe, L. Nat. Struct. Biol. (1997) [Pubmed]
  10. Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene. Fardella, C.E., Pinto, M., Mosso, L., Gómez-Sánchez, C., Jalil, J., Montero, J. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  11. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo, F., Pezzi, V., Barzon, L., Mulatero, P., Veglio, F., Sonino, N., Mathis, J.M. Eur. J. Endocrinol. (2002) [Pubmed]
  12. Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway. Chuman, Y., Zhan, Z., Fojo, T. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  13. Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta). Mornet, E., Dupont, J., Vitek, A., White, P.C. J. Biol. Chem. (1989) [Pubmed]
  14. CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity. Ganapathipillai, S., Laval, G., Hoffmann, I.S., Castejon, A.M., Nicod, J., Dick, B., Frey, F.J., Frey, B.M., Cubeddu, L.X., Ferrari, P. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  15. Expression of 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in the human fetal adrenal. Freije, W.A., Pezzi, V., Arici, A., Carr, B.R., Rainey, W.E. J. Soc. Gynecol. Investig. (1997) [Pubmed]
  16. Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. Kawamoto, T., Mitsuuchi, Y., Toda, K., Yokoyama, Y., Miyahara, K., Miura, S., Ohnishi, T., Ichikawa, Y., Nakao, K., Imura, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Functional maturation of the primate fetal adrenal in vivo: 3. Specific zonal localization and developmental regulation of CYP21A2 (P450c21) and CYP11B1/CYP11B2 (P450c11/aldosterone synthase) lead to integrated concept of zonal and temporal steroid biosynthesis. Coulter, C.L., Jaffe, R.B. Endocrinology (1998) [Pubmed]
  18. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. Mulatero, P., Curnow, K.M., Aupetit-Faisant, B., Foekling, M., Gomez-Sanchez, C., Veglio, F., Jeunemaitre, X., Corvol, P., Pascoe, L. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  19. Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase. Fisher, A., Friel, E.C., Bernhardt, R., Gomez-Sanchez, C., Connell, J.M., Fraser, R., Davies, E. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  20. Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Johansson, M.K., Sanderson, J.T., Lund, B.O. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
  21. Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1). Wang, X.L., Bassett, M., Zhang, Y., Yin, S., Clyne, C., White, P.C., Rainey, W.E. Endocrinology (2000) [Pubmed]
  22. Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase. Wang, Z.N., Bassett, M., Rainey, W.E. J. Mol. Endocrinol. (2001) [Pubmed]
  23. Inherited forms of mineralocorticoid hypertension. White, P.C. Hypertension (1996) [Pubmed]
  24. Effects of PCBs and MeSO(2)-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells. Xu, Y., Yu, R.M., Zhang, X., Murphy, M.B., Giesy, J.P., Lam, M.H., Lam, P.K., Wu, R.S., Yu, H. Chemosphere (2006) [Pubmed]
  25. Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. Lim, P.O., Macdonald, T.M., Holloway, C., Friel, E., Anderson, N.H., Dow, E., Jung, R.T., Davies, E., Fraser, R., Connell, J.M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  26. Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1. Bassett, M.H., Zhang, Y., Clyne, C., White, P.C., Rainey, W.E. J. Mol. Endocrinol. (2002) [Pubmed]
  27. Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. Pascoe, L., Jeunemaitre, X., Lebrethon, M.C., Curnow, K.M., Gomez-Sanchez, C.E., Gasc, J.M., Saez, J.M., Corvol, P. J. Clin. Invest. (1995) [Pubmed]
  28. Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1. Chabre, O., Portrat-Doyen, S., Chaffanjon, P., Vivier, J., Liakos, P., Labat-Moleur, F., Chambaz, E., Morel, Y., Defaye, G. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
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