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Gene Review

Cyp11b2  -  cytochrome P450, family 11, subfamily b,...

Mus musculus

Synonyms: Aldosterone synthase, CYPXIB2, Cpn2, Cyp11b, Cyp11b-2, ...
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Disease relevance of Cyp11b2

  • Physical mapping of overlapping cosmid and phage isolates defined two genes (designated Cyp11b-1 and Cyp11b-2 in the standard nomenclature for cytochrome P450 genes) that are oriented in the same direction and separated by approximately 8 kilobase pairs of DNA [1].
  • Accordingly, adrenal glands are enlarged because of hypertrophy of the cortex, resulting in increased expression of key cortical steroid biosynthetic enzymes, such as side-chain cleavage enzyme, steroid 11 beta-hydroxylase, and aldosterone synthase [2].

Psychiatry related information on Cyp11b2

  • In a time study experiment we found that P450C11 transformed the labeled-steroid into [14C]corticosterone, [14C]19-OH-deoxycorticosterone and [14C]18-OH-deoxycorticosterone in ratios of 1:1.11:0.07, after 2 h of incubation; no [14C]aldosterone could be detected [3].

High impact information on Cyp11b2


Biological context of Cyp11b2


Anatomical context of Cyp11b2


Associations of Cyp11b2 with chemical compounds


Regulatory relationships of Cyp11b2


Other interactions of Cyp11b2


  1. Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids. Domalik, L.J., Chaplin, D.D., Kirkman, M.S., Wu, R.C., Liu, W.W., Howard, T.A., Seldin, M.F., Parker, K.L. Mol. Endocrinol. (1991) [Pubmed]
  2. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Cole, T.J., Blendy, J.A., Monaghan, A.P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K., Schütz, G. Genes Dev. (1995) [Pubmed]
  3. The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity. Véronneau, S., Bernard, H., Cloutier, M., Courtemanche, J., Ducharme, L., Lefebvre, A., Mason, J.I., LeHoux, J.G. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  4. Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase. Mouw, A.R., Rice, D.A., Meade, J.C., Chua, S.C., White, P.C., Schimmer, B.P., Parker, K.L. J. Biol. Chem. (1989) [Pubmed]
  5. In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion. Takaya, J., Matsusaka, T., Katori, H., Tamura, M., Miyazaki, Y., Homma, T., Ichikawa, I. Mol. Endocrinol. (2001) [Pubmed]
  6. Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland. Allen, R.G., Carey, C., Parker, J.D., Mortrud, M.T., Mellon, S.H., Low, M.J. Mol. Endocrinol. (1995) [Pubmed]
  7. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Lee, G., Makhanova, N., Caron, K., Lopez, M.L., Gomez, R.A., Smithies, O., Kim, H.S. Endocrinology (2005) [Pubmed]
  8. Kidney function in mice lacking aldosterone. Makhanova, N., Lee, G., Takahashi, N., Sequeira Lopez, M.L., Gomez, R.A., Kim, H.S., Smithies, O. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  9. Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction. Katada, J., Meguro, T., Saito, H., Ohashi, A., Anzai, T., Ogawa, S., Yoshikawa, T. Circulation (2005) [Pubmed]
  10. Aldosterone synthase activity in the Y-1 adrenal cell line. Es-souni Routhier, M., Bournot, P., Ramirez, L.C. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  11. Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1. Bassett, M.H., Zhang, Y., Clyne, C., White, P.C., Rainey, W.E. J. Mol. Endocrinol. (2002) [Pubmed]
  12. Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Keeney, D.S., Jenkins, C.M., Waterman, M.R. Endocrinology (1995) [Pubmed]
  13. Acute in vivo effects of ACTH by exo utero microinjection on differentiation, steroidogenesis and proliferation of fetal mouse adrenocytes. Zhang, H., Hatta, T., Ma, L., Hashimoto, R., Kihara, I., Otani, H. Endocr. Res. (1999) [Pubmed]
  14. Physiological impact of increased expression of the AT1 angiotensin receptor. Le, T.H., Kim, H.S., Allen, A.M., Spurney, R.F., Smithies, O., Coffman, T.M. Hypertension (2003) [Pubmed]
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