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Gene Review

WASF3  -  WAS protein family, member 3

Homo sapiens

Synonyms: Brush-1, KIAA0900, Protein WAVE-3, SCAR3, Verprolin homology domain-containing protein 3, ...
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Disease relevance of WASF3


Psychiatry related information on WASF3


High impact information on WASF3

  • The opposite was true for WAVE1, and neither precipitated WAVE3, suggesting that WAVE isoforms have different affinities to these ligands, while the SH3 domain of abl binds to all 3 isoforms [11].
  • The precise role of WAVE3 in cell migration and its regulation, however, have not been elucidated [12].
  • WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase [12].
  • The mean number of symptoms was higher among survivors compared with control subjects at wave 2 (7.5 vs 5.8 symptoms) and at wave 3 (6.1 vs 4.9 symptoms) (P < .001 for both) [13].
  • We also show that the downstream effect of the WAVE3 knockdown is the inhibition of cell motility and invasion, coupled with increased actin stress fiber formation, as well as reorganization of focal adhesion complexes [14].

Biological context of WASF3

  • WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility [14].
  • WAVE3 was strongly expressed in brain and mapped on chromosome 13q12 [15].
  • Knockdown of WAVE3 expression by RNA interference prevented the PDGF-induced lamellipodia formation and cell migration [12].
  • Consistently monitoring caloric intake at Waves 1 and 2 predicted better self-rated health (p < .05), greater energy (p < .01), and positive change in health (p < .05) at Wave 3 in models that adjusted for the above set of control variables [16].
  • Similarly, increased risk of IPV at wave 3 was associated with self-reported STIs (OR=2.0, p=.03), and unprotected anal sex (OR= 2.0, p<.01); always requesting that partners use condoms was associated with a significant decrease in subsequent IPV (OR=.18, p<.01) [17].

Anatomical context of WASF3

  • Ectopically expressed WAVE2 and WAVE3 induced actin filament clusters in a similar manner with WAVE1 [15].
  • Here we show that endogenous WAVE3 was found to be concentrated in the lamellipodia at the leading edge of migrating MDA-MB-231 cells [12].
  • 3) MCs, SMCs (5 x 10(6)/rat), or media were injected into a transmural scar 3 wk after cryoinjury in rat hearts (n = 12 rats per group), and heart function, blood vessel density, and myocardial scar size and thickness were evaluated 5 wk later [18].
  • In control animals, the wounded muscle showed oedema, erythrocyte extravasation and myonecrosis both within and outside the immediate wounded area (5-10 mm zone) and influx of neutrophils was detected 30 min post-wound, followed by a second wave 3 hr later [19].

Associations of WASF3 with chemical compounds


Regulatory relationships of WASF3

  • Wave 1 genetic factors accounted for continuity of symptoms at waves 2 and 3. 'New'genetic effects at wave 2 also influenced wave 3 symptoms [22].

Other interactions of WASF3


Analytical, diagnostic and therapeutic context of WASF3


  1. The structure of genetic and environmental risk factors for three measures of disordered eating. Wade, T., Martin, N.G., Neale, M.C., Tiggemann, M., Treloar, S.A., Bucholz, K.K., Madden, P.A., Heath, A.C. Psychological medicine. (1999) [Pubmed]
  2. Trends of HIV infection among injection drug users in Brazil in the 1990s: the impact of changes in patterns of drug use. Mesquita, F., Kral, A., Reingold, A., Bueno, R., Trigueiros, D., Araujo, P.J. J. Acquir. Immune Defic. Syndr. (2001) [Pubmed]
  3. Work schedule, needle use, and needlestick injuries among registered nurses. Trinkoff, A.M., Le, R., Geiger-Brown, J., Lipscomb, J. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America (2007) [Pubmed]
  4. Outcome of percutaneous coronary intervention in unstable angina pectoris versus stable angina pectoris in two different time periods. Naidu, S.S., Polin, G.M., Selzer, F., Laskey, W.K., Jacobs, A.K., Williams, D.O., Wilensky, R.L. Am. J. Cardiol. (2006) [Pubmed]
  5. Acquired progressive lymphangioma of the skin following radiotherapy for breast carcinoma. Rosso, R., Gianelli, U., Carnevali, L. J. Cutan. Pathol. (1995) [Pubmed]
  6. Longitudinal direct and indirect pathways linking older sibling competence to the development of younger sibling competence. Brody, G.H., Kim, S., Murry, V.M., Brown, A.C. Developmental psychology. (2003) [Pubmed]
  7. Associations between drug abuse treatment and cigarette use: evidence of substance replacement. Conner, B.T., Stein, J.A., Longshore, D., Stacy, A.W. Experimental and clinical psychopharmacology. (1999) [Pubmed]
  8. Symptoms of depression in the oldest old: a longitudinal study. Haynie, D.A., Berg, S., Johansson, B., Gatz, M., Zarit, S.H. The journals of gerontology. Series B, Psychological sciences and social sciences. (2001) [Pubmed]
  9. Positive parenting as a mediator of the relations between parental psychological distress and mental health problems of parentally bereaved children. Kwok, O.M., Haine, R.A., Sandler, I.N., Ayers, T.S., Wolchik, S.A., Tein, J.Y. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. (2005) [Pubmed]
  10. Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Schulze, T.G., Buervenich, S., Badner, J.A., Steele, C.J., Detera-Wadleigh, S.D., Dick, D., Foroud, T., Cox, N.J., MacKinnon, D.F., Potash, J.B., Berrettini, W.H., Byerley, W., Coryell, W., DePaulo, J.R., Gershon, E.S., Kelsoe, J.R., McInnis, M.G., Murphy, D.L., Reich, T., Scheftner, W., Nurnberger, J.I., McMahon, F.J. Biol. Psychiatry (2004) [Pubmed]
  11. WAVE/Scars in platelets. Oda, A., Miki, H., Wada, I., Yamaguchi, H., Yamazaki, D., Suetsugu, S., Nakajima, M., Nakayama, A., Okawa, K., Miyazaki, H., Matsuno, K., Ochs, H.D., Machesky, L.M., Fujita, H., Takenawa, T. Blood (2005) [Pubmed]
  12. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. Sossey-Alaoui, K., Li, X., Ranalli, T.A., Cowell, J.K. J. Biol. Chem. (2005) [Pubmed]
  13. Symptoms and related functioning in a traumatized community. van den Berg, B., Grievink, L., Stellato, R.K., Yzermans, C.J., Lebret, E. Arch. Intern. Med. (2005) [Pubmed]
  14. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. Sossey-Alaoui, K., Ranalli, T.A., Li, X., Bakin, A.V., Cowell, J.K. Exp. Cell Res. (2005) [Pubmed]
  15. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Suetsugu, S., Miki, H., Takenawa, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  16. Health behaviors associated with better quality of life for older bereaved persons. Chen, J.H., Gill, T.M., Prigerson, H.G. Journal of palliative medicine. (2005) [Pubmed]
  17. HIV and intimate partner violence among methadone-maintained women in New York City. El-Bassel, N., Gilbert, L., Wu, E., Go, H., Hill, J. Social science & medicine (1982) (2005) [Pubmed]
  18. Myometrial cells induce angiogenesis and salvage damaged myocardium. Huang, M.L., Tian, H., Wu, J., Matsubayashi, K., Weisel, R.D., Li, R.K. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  19. Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat. Zerria, K., Jerbi, E., Hammami, S., Maaroufi, A., Boubaker, S., Xiong, J.P., Arnaout, M.A., Fathallah, D.M. Immunology (2006) [Pubmed]
  20. Relationship between drug abuse and intimate partner violence: a longitudinal study among women receiving methadone. El-Bassel, N., Gilbert, L., Wu, E., Go, H., Hill, J. American journal of public health. (2005) [Pubmed]
  21. c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. Sossey-Alaoui, K., Li, X., Cowell, J.K. J. Biol. Chem. (2007) [Pubmed]
  22. Changes in genetic and environmental influences on depressive symptoms across adolescence and young adulthood. Lau, J.Y., Eley, T.C. The British journal of psychiatry : the journal of mental science. (2006) [Pubmed]
  23. Genetic influences on quantity of alcohol consumed by adolescents and young adults. Hopfer, C.J., Timberlake, D., Haberstick, B., Lessem, J.M., Ehringer, M.A., Smolen, A., Hewitt, J.K. Drug and alcohol dependence. (2005) [Pubmed]
  24. Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. Yip, A.G., Brayne, C., Easton, D., Rubinsztein, D.C. J. Med. Genet. (2002) [Pubmed]
  25. Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage. Kashiwagi, H., Shiraga, M., Kato, H., Honda, S., Sako, M., Kurata, Y., Kanakura, Y., Tomiyama, Y. J. Thromb. Haemost. (2005) [Pubmed]
  26. Importance of the postdischarge interval in assessing major adverse clinical event rates following percutaneous coronary intervention. Laskey, W.K., Selzer, F., Jacobs, A.K., Cohen, H.A., Holmes, D.R., Wilensky, R.L., Detre, K.M., Williams, D.O. Am. J. Cardiol. (2005) [Pubmed]
  27. Predictors and Sequelae of Fractures in the Elderly: The Canadian Study of Health and Aging (CSHA). Ostbye, T., Walton, R.E., Steenhuis, R., Hodsman, A.B. Canadian journal on aging = La revue canadienne du vieillissement. (2004) [Pubmed]
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