Disease relevance of WASF3

• RESULTS: As only one twin pair was concordant for lifetime bulimia nervosa at Wave 3 assessment, ordinal measures of all assessments were used in a multivariate genetic analysis [1].
• HIV seroprevalence was 63% in wave 1, 65% in wave 2, and 42% in wave 3 ( p <.001) [2].
• Of the nurses, 15.6% reported a history of needlestick injury in the year before wave 1, and the cumulative incidence by wave 3 was 16.3% [3].
• However, in patients with SAP, the adjusted rate for death/myocardial infarction was lower in wave 3, and for death, myocardial infarction, and revascularization, there was a significant decrease in event rates with each successive recruitment period (p < 0.05 for all comparisons) [4].
• The lesion appeared in the skin close to a mastectomy scar 3 years after surgery and radiotherapy for invasive ductal carcinoma [5].

Psychiatry related information on WASF3

• Mothers' Wave 2 psychological functioning was associated with involved-supportive parenting of the YS at Wave 3 [6].
• Risk-behavior bias predicted more drug and cigarette use and predicted less participation in drug treatment at Wave 3 [7].
• At Wave 3, depressive symptoms increased slightly but not significantly [8].
• However, the longitudinal model did find a significant path from positive parenting at Wave 2 to child mental health problems 11 months later at Wave 3, controlling for stability in child mental health problems [9].
• BACKGROUND: We have reported genetic linkage between bipolar disorder and markers on chromosome 6q16.3-22.1 in the National Institute of Mental Health Genetics Initiative wave 3 pedigrees [10].

High impact information on WASF3

• The opposite was true for WAVE1, and neither precipitated WAVE3, suggesting that WAVE isoforms have different affinities to these ligands, while the SH3 domain of abl binds to all 3 isoforms [11].
• The precise role of WAVE3 in cell migration and its regulation, however, have not been elucidated [12].
• WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase [12].
• The mean number of symptoms was higher among survivors compared with control subjects at wave 2 (7.5 vs 5.8 symptoms) and at wave 3 (6.1 vs 4.9 symptoms) (P < .001 for both) [13].
• We also show that the downstream effect of the WAVE3 knockdown is the inhibition of cell motility and invasion, coupled with increased actin stress fiber formation, as well as reorganization of focal adhesion complexes [14].

Biological context of WASF3

• WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility [14].
• WAVE3 was strongly expressed in brain and mapped on chromosome 13q12 [15].
• Knockdown of WAVE3 expression by RNA interference prevented the PDGF-induced lamellipodia formation and cell migration [12].
• Consistently monitoring caloric intake at Waves 1 and 2 predicted better self-rated health (p < .05), greater energy (p < .01), and positive change in health (p < .05) at Wave 3 in models that adjusted for the above set of control variables [16].
• Similarly, increased risk of IPV at wave 3 was associated with self-reported STIs (OR=2.0, p=.03), and unprotected anal sex (OR= 2.0, p<.01); always requesting that partners use condoms was associated with a significant decrease in subsequent IPV (OR=.18, p<.01) [17].

Anatomical context of WASF3

• Ectopically expressed WAVE2 and WAVE3 induced actin filament clusters in a similar manner with WAVE1 [15].
• Here we show that endogenous WAVE3 was found to be concentrated in the lamellipodia at the leading edge of migrating MDA-MB-231 cells [12].
• 3) MCs, SMCs (5 x 10(6)/rat), or media were injected into a transmural scar 3 wk after cryoinjury in rat hearts (n = 12 rats per group), and heart function, blood vessel density, and myocardial scar size and thickness were evaluated 5 wk later [18].
• In control animals, the wounded muscle showed oedema, erythrocyte extravasation and myonecrosis both within and outside the immediate wounded area (5-10 mm zone) and influx of neutrophils was detected 30 min post-wound, followed by a second wave 3 hr later [19].

Associations of WASF3 with chemical compounds

• METHODS: A random sample of 416 women on methadone was assessed at baseline (wave 1) and at 6 months (wave 2), and 12 months (wave 3) following the initial assessment [20].
• We have also shown that Abl targets and phosphorylates four tyrosine residues in WAVE3 and that the Abl-dependent phosphorylation of WAVE3 is critical for the stimulation of lamellipodia formation and cell migration [21].

Regulatory relationships of WASF3

• Wave 1 genetic factors accounted for continuity of symptoms at waves 2 and 3. 'New'genetic effects at wave 2 also influenced wave 3 symptoms [22].

Other interactions of WASF3

• We named the original WAVE1 and newly identified ones WAVE2 and WAVE3 [15].
• DRD2 TaqI A1/A2 was associated at Wave 3 (p=0.007) [23].
• MMSE scores at wave 3 and the difference in MMSE between baseline and at the third assessment wave were not different across APOE genotypes [24].

Analytical, diagnostic and therapeutic context of WASF3

• Immunoblotting and immunohistochemical analysis revealed that platelets expressed WAVE-1 and WAVE-2, whereas WAVE-3 expression was hardly to be detected [25].
• METHODS: During 1991 through 1992 (wave 1; n = 214), 1994 through 1996 (wave 2; n = 135), and 1999 (wave 3; n = 108), we conducted three cross-sectional studies of IDUs [2].
• Mean length of stay decreased (2.7 days for wave 1, 2.2 days for wave 3, p <0.001) [26].
• Data are from the Canadian Study of Health and Aging (CSHA), a longitudinal cohort study, collected in three waves: baseline (1991), wave 2 (1996), and wave 3 (2001) [27].
• Quality of life was assessed at approximately 11 months postloss and 19 months postloss (Wave 3), using the RAND 36-Item Health Survey, which measures 8 domains of health and functioning, plus a single item assessing change in health [16].

References