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Gene Review

Klf4  -  Kruppel-like factor 4 (gut)

Mus musculus

Synonyms: EZF, Epithelial zinc finger protein EZF, Ezf, Gklf, Gut-enriched krueppel-like factor, ...
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Disease relevance of Klf4

  • Klf4 mutants also display aberrant expression of acidic mucins and TFF2/SP-positive cells, findings characteristic of premalignant conditions, but no inflammation, intestinal metaplasia, dysplasia, or cancer up to 1 year of age [1].
  • Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells [2].
  • Kr??ppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias [3].
  • Klf4-deficient mice fail to establish the barrier function of the skin and die shortly after birth due to dehydration [4].

High impact information on Klf4


Biological context of Klf4


Anatomical context of Klf4


Associations of Klf4 with chemical compounds

  • The KLF4 induction of the iNOS promoter is mediated by two KLF DNA-binding sites at -95 and -212 bp, and mutation of these sites diminished induction by IFN-gamma and LPS [10].
  • GKLF induction by H-Fe is mediated through hydroxyl radicals, p38MAP kinase-, calcium-, and protein synthesis-dependent pathways [12].

Regulatory relationships of Klf4

  • Furthermore, GKLF was not highly expressed in differentiated SMCs in vivo, and TGF-beta down-regulated GKLF expression in dedifferentiated cultured SMCs [13].

Other interactions of Klf4

  • Here, we examined the developmental expression of the mouse Klf5 gene and compared it to the established pattern of the Klf4 gene [11].
  • We have used real-time PCR to confirm the changes in levels of transcripts such as renin-1, Kruppel-like factor 4, Mad4 (max-interacting protein repressor), Nur-related protein 1, and hairy/enhancer of splits gene 1 that were found to be regulated by FSH in testes of hpg mice [14].


  1. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Katz, J.P., Perreault, N., Goldstein, B.G., Actman, L., McNally, S.R., Silberg, D.G., Furth, E.E., Kaestner, K.H. Gastroenterology (2005) [Pubmed]
  2. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Swamynathan, S.K., Katz, J.P., Kaestner, K.H., Ashery-Padan, R., Crawford, M.A., Piatigorsky, J. Mol. Cell. Biol. (2007) [Pubmed]
  3. KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Kharas, M.G., Yusuf, I., Scarfone, V.M., Yang, V.W., Segre, J.A., Huettner, C.S., Fruman, D.A. Blood (2007) [Pubmed]
  4. Developmental and cell type-specific expression of the zinc finger transcription factor Krüppel-like factor 4 (Klf4) in postnatal mouse testis. Behr, R., Kaestner, K.H. Mech. Dev. (2002) [Pubmed]
  5. Complex redundancy to build a simple epidermal permeability barrier. Segre, J. Curr. Opin. Cell Biol. (2003) [Pubmed]
  6. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Li, Y., McClintick, J., Zhong, L., Edenberg, H.J., Yoder, M.C., Chan, R.J. Blood (2005) [Pubmed]
  7. Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Jaubert, J., Cheng, J., Segre, J.A. Development (2003) [Pubmed]
  8. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Katz, J.P., Perreault, N., Goldstein, B.G., Lee, C.S., Labosky, P.A., Yang, V.W., Kaestner, K.H. Development (2002) [Pubmed]
  9. The mouse Krüppel-like Factor 4 (Klf4) gene: four functional polyadenylation sites which are used in a cell-specific manner as revealed by testicular transcript analysis and multiple processed pseudogenes. Godmann, M., Kromberg, I., Mayer, J., Behr, R. Gene (2005) [Pubmed]
  10. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. Feinberg, M.W., Cao, Z., Wara, A.K., Lebedeva, M.A., Senbanerjee, S., Jain, M.K. J. Biol. Chem. (2005) [Pubmed]
  11. Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Ohnishi, S., Laub, F., Matsumoto, N., Asaka, M., Ramirez, F., Yoshida, T., Terada, M. Dev. Dyn. (2000) [Pubmed]
  12. Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. Nickenig, G., Baudler, S., Müller, C., Werner, C., Werner, N., Welzel, H., Strehlow, K., Böhm, M. FASEB J. (2002) [Pubmed]
  13. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. Adam, P.J., Regan, C.P., Hautmann, M.B., Owens, G.K. J. Biol. Chem. (2000) [Pubmed]
  14. Follicle-stimulating hormone induced changes in gene expression of murine testis. Sadate-Ngatchou, P.I., Pouchnik, D.J., Griswold, M.D. Mol. Endocrinol. (2004) [Pubmed]
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