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Gene Review

Myh11  -  myosin, heavy chain 11, smooth muscle

Rattus norvegicus

Synonyms: Myosin heavy chain 11, Myosin heavy chain, smooth muscle isoform, Myosin-11, SMMHC
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Disease relevance of RGD1564935_predicted


High impact information on RGD1564935_predicted

  • To address this issue, we made monospecific rabbit polyclonal antibodies against the difference peptide for the SM-B smooth-muscle myosin heavy chain (SMMHC) and used these to investigate the distribution of the SM-B isoform in lung [2].
  • During development, reactivity is first seen in the trachea and bronchi of saccular lung at the time of birth, when other SMMHC isoforms also are present [2].
  • Cells expressing PKG, but not control adenovirus-infected cells, began to express a specific marker protein for the contractile phenotype, smooth muscle myosin heavy chain (SMMHC), within 48 hours of PKG induction [3].
  • TGF-beta up-regulated both transcription and mRNA levels but did not change the proportions of SMMHC mRNAs [4].
  • Moreover, short interfering RNA (siRNA) specific for myocardin attenuated depolarization-induced SMMHC/SM alpha-actin transcription [5].

Biological context of RGD1564935_predicted


Associations of RGD1564935_predicted with chemical compounds

  • In normal salivary glands included in these sections, the myoepithelial cells (MECs) expressed alpha-smooth muscle actin (alphaSMA) and smooth muscle myosin heavy chain (SMMHC), whereas the duct luminal cells expressed keratins 19, 18 and 8 [6].
  • The ROK inhibitor, Y-27632, prevented depolarization-induced increase in SMMHC/SM alpha-actin but had no effect on c-fos expression [5].
  • Depolarization-induced activation of VGCCs resulted in a nifedipine-sensitive increase in endogenous smooth muscle myosin heavy chain (SMMHC) and SM alpha-actin expression and CArG-dependent promoter activity, as well as c-fos promoter activity [5].

Other interactions of RGD1564935_predicted

  • Conversely, the Ca2+/calmodulin-dependent kinase inhibitor, KN93, prevented depolarization-induced increases in c-fos expression with no effect on SMMHC/SM alpha-actin [5].

Analytical, diagnostic and therapeutic context of RGD1564935_predicted


  1. Microvessel precursor smooth muscle cells express head-inserted smooth muscle myosin heavy chain (SM-B) isoform in hyperoxic pulmonary hypertension. Jones, R., Steudel, W., White, S., Jacobson, M., Low, R. Cell Tissue Res. (1999) [Pubmed]
  2. Smooth-muscle myosin heavy-chain SM-B isoform expression in developing and adult rat lung. Low, R.B., Mitchell, J., Woodcock-Mitchell, J., Rovner, A.S., White, S.L. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  3. Inhibition of cGMP-dependent protein kinase reverses phenotypic modulation of vascular smooth muscle cells. Dey, N.B., Foley, K.F., Lincoln, T.M., Dostmann, W.R. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  4. Age dependence of smooth muscle myosin expression by cultured rat aortic smooth muscle cells. Low, R.B., White, S.L., Low, E.S., Neuville, P., Bochaton-Piallat, M.L., Gabbiani, G. Differentiation (1999) [Pubmed]
  5. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Wamhoff, B.R., Bowles, D.K., McDonald, O.G., Sinha, S., Somlyo, A.P., Somlyo, A.V., Owens, G.K. Circ. Res. (2004) [Pubmed]
  6. Plasmacytoid cells in salivary-gland pleomorphic adenomas: evidence of luminal cell differentiation. Ogawa, Y., Kishino, M., Atsumi, Y., Kimoto, M., Fukuda, Y., Ishida, T., Ijuhin, N. Virchows Arch. (2003) [Pubmed]
  7. Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells. Kobayashi, N., Yasu, T., Ueba, H., Sata, M., Hashimoto, S., Kuroki, M., Saito, M., Kawakami, M. Exp. Hematol. (2004) [Pubmed]
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