Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Pvt1_mapped - plasmacytoma variant translocation 1 (mapped)

Rattus norvegicus

This record was discontinued.

Lazo, P.A. et al., Tsichlis, P.N. et al., Ingvarsson, S. et al., Huppi, K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pvt1_mapped

In plasmacytomas with rcpt(6;15) translocations, the Pvt-1 transcripts are elevated in abundance and truncated in size [1].
Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas [2].
To determine whether Myc expression was also affected by these provirus insertions, we constructed T-cell hybrids between two rat thymic lymphomas containing a provirus in Mlvi-4 or Mlvi-1 and the murine T-cell lymphoma line BW5147 [2].
T-cell lymphomas induced by Moloney murine leukemia virus frequently have proviruses integrated at the Mlvi-4 and Mlvi-1 loci, which map approximately 30 and 270 kilobases 3' of the promoter region of the Myc protooncogene, respectively [2].

High impact information on Pvt1_mapped

The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7 [3].
The Pvt-1 locus is also involved in mouse plasmacytoma (6;15) and in the variant Burkitt lymphoma (2;8) translocations [3].

Biological context of Pvt1_mapped

Rat thymic lymphomas induced by Moloney murine leukemia virus carry DNA rearrangements due to provirus integration in at least five independent cellular DNA domains (Mlvi-1, Mlvi-2, Mlvi-3, RMoInt-1, and c-myc) [4].

Analytical, diagnostic and therapeutic context of Pvt1_mapped

Using an S1 nuclease protection assay, we observed that the expression of the rat Myc cosegregated with the rearranged Mlvi-4 or Mlvi-1 locus [2].

References

Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas. Huppi, K., Siwarski, D., Skurla, R., Klinman, D., Mushinski, J.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Lazo, P.A., Lee, J.S., Tsichlis, P.N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7. Ingvarsson, S., Wirschubsky, Z., Szpirer, J., Levan, G., Klein, G., Sümegi, J. Cytogenet. Cell Genet. (1987) [Pubmed]
Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis. Tsichlis, P.N., Strauss, P.G., Lohse, M.A. J. Virol. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.