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Gene Review:

gpt2 - UDP-N-acetylglucosamine--dolichyl...

Schizosaccharomyces pombe 972h-

Synonyms: alg7, gpt

Zou, J. et al., Scocca, J.R. et al., Sorensen, T.K. et al.

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High impact information on gpt

S. pombe cells containing a chromosomal deletion of the essential gpt+ gene are rescued by a plasmid containing the S. pombe gpt open reading frame [1].
The S. pombe gpt gene was mapped to chromosome 2 near top1 and ade1 [2].
Overexpression of the gpt gene in S. pombe cells increased resistance to tunicamycin 25-fold and increased the specific activity of the enzyme in isolated cell membranes 13-fold [2].

Analytical, diagnostic and therapeutic context of gpt

A complete cDNA clone of A. niger gpt was obtained by employing a recombinant PCR approach [3].

References

Aspartic acid 252 and asparagine 185 are essential for activity of lipid N-acetylglucosaminylphosphate transferase. Scocca, J.R., Krag, S.S. Glycobiology (1997) [Pubmed]
Asparagine-linked glycosylation in Schizosaccharomyces pombe: functional conservation of the first step in oligosaccharide-lipid assembly. Zou, J., Scocca, J.R., Krag, S.S. Arch. Biochem. Biophys. (1995) [Pubmed]
Characterisation of the gptA gene, encoding UDP N-acetylglucosamine: dolichol phosphate N-acetylglucosaminylphosphoryl transferase, from the filamentous fungus, Aspergillus niger. Sorensen, T.K., Dyer, P.S., Fierro, F., Laube, U., Peberdy, J.F. Biochim. Biophys. Acta (2003) [Pubmed]

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AgaP_AGAP008131	Anopheles gambiae str. PEST
AT3G57220	Arabidopsis thaliana
GPT	Arabidopsis thaliana
AGOS_AFL037W	Ashbya gossypii ATCC 10895
DPAGT1	Bos taurus
CELE_Y60A3A.14	Caenorhabditis elegans
DPAGT1	Canis lupus familiaris
dpagt1	Danio rerio
CG5287	Drosophila melanogaster
DPAGT1	Gallus gallus
DPAGT1	Homo sapiens
KLLA0F06776g	Kluyveromyces lactis NRRL Y-1140
DPAGT1	Macaca mulatta
MGG_01559	Magnaporthe oryzae 70-15
Dpagt1	Mus musculus
NCU10762	Neurospora crassa OR74A
Os07g0661100	Oryza sativa Japonica Group
DPAGT1	Pan troglodytes
Dpagt1	Rattus norvegicus
ALG7	Saccharomyces cerevisiae S288c
LOC100487779	Xenopus (Silurana) tropicalis

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