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Gene Review

Dpagt1  -  dolichyl-phosphate (UDP-N...

Mus musculus

Synonyms: AU021132, Dpagt2, G1PT, GPT, GlcNAc-1-P transferase, ...
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Disease relevance of Dpagt1

  • Primary cultures of fetal murine cortical neurons were subjected to paradigms of either exogenous or endogenous glutamate toxicity to evaluate the neuroprotective value of GPT [1].
  • The preventive effect of CAT on a hepatic ischemia/reperfusion injury was examined in mice by measuring the GOT and GPT levels in plasma [2].

High impact information on Dpagt1


Biological context of Dpagt1

  • The 3'-end reverse transcription-polymerase chain reaction analysis indicated that the first of the two polyadenylation sites was used predominantly, in agreement with a approximately 2.0-kilobase pair GPT message seen on Northern blots of RNA from a wide variety of mouse tissues [5].
  • Transcription from the promoter containing the mutated direct repeats was increased greatly, consistent with the conclusion that these motifs functions in vivo to repress GPT gene expression [4].
  • With the use of a panel of mouse/hamster somatic-cell hybrids and a specific probe derived from the 3'-non-coding region of the mouse cDNA, the GPT gene was mapped to mouse chromosome 17 [6].
  • An antiserum raised against a 15-residue peptide, derived from the predicted amino acid sequence of the cloned mouse cDNA, specifically precipitated the activity of GPT from solubilized mouse mammary gland microsomes, and detected a protein of about 48 kDa on Western blot [6].
  • These results indicate that GPT function is essential in early embryogenesis and suggest that N-glycosylation is needed for the viability of cells comprising the peri-implantation stage embryo [7].

Anatomical context of Dpagt1


Associations of Dpagt1 with chemical compounds


Regulatory relationships of Dpagt1

  • The results showed that co-transfection of STAT5a or prolactin receptor can enhance Dpagt2 promoter activities in the promoter construct pGL-MX6 (from base pairs -386 to -5), but not in the promoter construct pGL-MX7 (from base pairs -322 to -5) [8].

Other interactions of Dpagt1

  • This size is in good agreement with that predicted from the cDNA sequence, and also with that (46 and 50 kDa) of purified bovine GPT [6].

Analytical, diagnostic and therapeutic context of Dpagt1


  1. Enzymatic degradation protects neurons from glutamate excitotoxicity. Matthews, C.C., Zielke, H.R., Wollack, J.B., Fishman, P.S. J. Neurochem. (2000) [Pubmed]
  2. Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice. Yabe, Y., Koyama, Y., Nishikawa, M., Takakura, Y., Hashida, M. Free Radic. Res. (1999) [Pubmed]
  3. Selective cytotoxicity of purified homologues of tunicamycin on transformed BALB/3T3 fibroblasts. Seiberg, M., Duksin, D. Cancer Res. (1983) [Pubmed]
  4. Negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland. Ma, J., Saito, H., Oka, T., Vijay, I.K. J. Biol. Chem. (1996) [Pubmed]
  5. Structure and organization of mouse GlcNAc-1-phosphate transferase gene. Rajput, B., Ma, J., Vijay, I.K. J. Biol. Chem. (1994) [Pubmed]
  6. Mouse UDP-GlcNAc: dolichyl-phosphate N-acetylglucosaminephosphotransferase. Molecular cloning of the cDNA, generation of anti-peptide antibodies and chromosomal localization. Rajput, B., Ma, J., Muniappa, N., Schantz, L., Naylor, S.L., Lalley, P.A., Vijay, I.K. Biochem. J. (1992) [Pubmed]
  7. A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality. Marek, K.W., Vijay, I.K., Marth, J.D. Glycobiology (1999) [Pubmed]
  8. STAT5a regulates the GlcNAc-1-phosphate transferase gene transcription and expression. Zhang, X.L., Qu, X.J., Vijay, I.K. Cell. Physiol. Biochem. (2003) [Pubmed]
  9. Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice. Chen, W.C., Hau, D.M., Chen, K.T., Wang, M.I., Lin, I.H. Am. J. Chin. Med. (1996) [Pubmed]
  10. The acute, genetic, developmental, and inhalation toxicology of 1,1,1,3,3-pentafluoropropane (HFC 245fa). Rusch, G.M., Coombs, D., Hardy, C. Toxicol. Sci. (1999) [Pubmed]
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