Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

hus5 - SUMO conjugating enzyme Hus5

Schizosaccharomyces pombe 972h-

al-Khodairy, F. et al., Ho, J.C. et al., Yasugi, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on hus5

The hubc9 encoded protein shares a very high degree of amino acid sequence similarity with ScUBC9 and with the homologous hus5+ gene product of Schizosaccharomyces pombe [1].
In addition, hus5 deletion mutants are severely impaired in growth and exhibit high levels of abortive mitoses, suggesting a role for hus5+ in chromosome segregation [2].
To understand the role of hus5+ in cell cycle control we have characterized the phenotypes of the hus5 mutants and the hus5 gene disruption [2].
Sequence analysis has suggested that rad31 and hus5 encode components of the Pmt3 (SUMO) modification process in S.pombe [3].

Biological context of hus5

The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis [2].
The Schizosaccharomyces pombe rad31 and hus5 genes are required for the DNA damage response, as mutants defective in these genes are sensitive to DNA damaging agents, such as UV and ionising radiation and to the DNA synthesis inhibitor hydroxyurea (HU) [3].

References

Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Yasugi, T., Howley, P.M. Nucleic Acids Res. (1996) [Pubmed]
The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis. al-Khodairy, F., Enoch, T., Hagan, I.M., Carr, A.M. J. Cell. Sci. (1995) [Pubmed]
SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Ho, J.C., Warr, N.J., Shimizu, H., Watts, F.Z. Nucleic Acids Res. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP011076	Anopheles gambiae str. PEST
SCE1	Arabidopsis thaliana
AGOS_AER056C	Ashbya gossypii ATCC 10895
UBE2I	Bos taurus
UBE2I	Canis lupus familiaris
ube2ia	Danio rerio
lwr	Drosophila melanogaster
UBE2I	Gallus gallus
UBE2I	Homo sapiens
KLLA0E05039g	Kluyveromyces lactis NRRL Y-1140
UBE2I	Macaca mulatta
MGG_00970	Magnaporthe oryzae 70-15
Ube2i	Mus musculus
NCU04302	Neurospora crassa OR74A
Os03g0123100	Oryza sativa Japonica Group
Os10g0536000	Oryza sativa Japonica Group
UBE2I	Pan troglodytes
Ube2i	Rattus norvegicus
UBC9	Saccharomyces cerevisiae S288c
ube2i	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.