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Gene Review

UBE2I  -  ubiquitin-conjugating enzyme E2I

Gallus gallus

Synonyms: UBC9, UBCE9
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High impact information on UBE2I

  • Ubc9 is essential for viability of higher eukaryotic cells [1].
  • A considerable portion of the Ubc9-depleted cell population was committed to apoptosis without accumulating in a specific phase of the cell cycle, suggesting that chromosome damages are accumulated in Ubc9-depleted cells, and apoptosis is triggered without activating checkpoint mechanisms under conditions of SUMO-1 conjugation system impairment [1].
  • Ubc9 disappeared 3 days after the addition of tetracycline and the increase in viable cell number stopped 4 days after the addition of drug [1].


  1. Ubc9 is essential for viability of higher eukaryotic cells. Hayashi, T., Seki, M., Maeda, D., Wang, W., Kawabe, Y., Seki, T., Saitoh, H., Fukagawa, T., Yagi, H., Enomoto, T. Exp. Cell Res. (2002) [Pubmed]
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