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Gene Review

lwr  -  lesswright

Drosophila melanogaster

Synonyms: CG3018, DUbc9, DmUbc9, Dmel\CG3018, Dmubc9, ...
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High impact information on lwr


Biological context of lwr


Anatomical context of lwr

  • Here, we demonstrate that lwr function regulates the production of blood cells (hemocytes) in Drosophila larvae. lwr mutant larvae develop many melanotic tumors in the hemolymph at the third instar stage [3].

Other interactions of lwr

  • The effect of DmUbc9 on Dorsal activity was potentiated by the overexpression of DmSmt3 [2].
  • Further, two-hybrid system analysis reveals DmUbc9 interaction with Drosophila and mammalian Hsp27 [7].

Analytical, diagnostic and therapeutic context of lwr

  • Highly conserved during evolution, the enzyme Ubc9 activates the small ubiquitin-like modifier (SUMO) prior to its covalent ligation to target proteins [8].


  1. Function of bicoid and hunchback homologs in the basal cyclorrhaphan fly Megaselia (Phoridae). Stauber, M., Taubert, H., Schmidt-Ott, U. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. A functional interaction between dorsal and components of the Smt3 conjugation machinery. Bhaskar, V., Valentine, S.A., Courey, A.J. J. Biol. Chem. (2000) [Pubmed]
  3. The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Huang, L., Ohsako, S., Tanda, S. Dev. Biol. (2005) [Pubmed]
  4. The Drosophila UBC9 homologue lesswright mediates the disjunction of homologues in meiosis I. Apionishev, S., Malhotra, D., Raghavachari, S., Tanda, S., Rasooly, R.S. Genes Cells (2001) [Pubmed]
  5. The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis. Epps, J.L., Tanda, S. Curr. Biol. (1998) [Pubmed]
  6. Characterisation of the murine Hox-3.3 gene and its promoter. Coletta, P.L., Shimeld, S.M., Chaudhuri, C., Müller, U., Clarke, J.P., Sharpe, P.T. Mech. Dev. (1991) [Pubmed]
  7. Cloning and developmental expression of a nuclear ubiquitin-conjugating enzyme (DmUbc9) that interacts with small heat shock proteins in Drosophila melanogaster. Joanisse, D.R., Inaguma, Y., Tanguay, R.M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila. Chiu, H., Ring, B.C., Sorrentino, R.P., Kalamarz, M., Garza, D., Govind, S. Dev. Biol. (2005) [Pubmed]
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