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Gene Review:

LPCAT4 - lysophosphatidylcholine acyltransferase 4

Homo sapiens

Synonyms: 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerol-3-phosphate O-acyltransferase 7, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, ...

Ye, G.M. et al., Cao, J. et al.

Jingsong Cao, Dandan Shan, Tracy Revett, Dongmei Li, Leeying Wu, Wei Liu, James F. Tobin, Ruth E. Gimeno,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AGPAT7

RT PCR amplification in 18 human tissues indicated that human AGPAT7 gene was widely expressed in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung and testis [1].
AGPAT7 protein was mainly localized to the endoplasmic reticulum (ER) in Hela cells [1].
Here we report the cloning and characterization of another novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase member AGPAT7 (1-acyl-sn-glycerol-3-phosphate acyltransferase 7) gene, which was mapped to human chromosome 15q14 [1].

Associations of AGPAT7 with chemical compounds

These findings identify LPEAT2 as an important enzyme in the biosynthesis of ethanolamine-containing phospholipids, especially in brain [2].

References

Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7. Ye, G.M., Chen, C., Huang, S., Han, D.D., Guo, J.H., Wan, B., Yu, L. DNA Seq. (2005) [Pubmed]
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. Cao, J., Shan, D., Revett, T., Li, D., Wu, L., Liu, W., Tobin, J.F., Gimeno, R.E. J. Biol. Chem. (2008) [Pubmed]

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