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Gene Review:

Hmmr - hyaluronan mediated motility receptor (RHAMM)

Rattus norvegicus

Synonyms: Hyaluronan-mediated motility receptor, Ihabp, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, Rhamm

Zaman, A. et al., Shakib, K. et al.

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Disease relevance of Hmmr

Taken together with previous results showing the inhibitory effects of HA-binding peptide on inflammation and fibrosis, we conclude that the interaction of RHAMM with HA is a critical component of the recruitment of inflammatory cells to the lung after injury [1].

High impact information on Hmmr

Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury [1].
Immunostaining showed increased expression of RHAMM in macrophages 4-7 d after injury [1].
Further, HA-stimulated macrophage chemotaxis was also inhibited by R36 [1].
Time-lapse cinemicrography demonstrated a 5-fold increase in motility of alveolar macrophages from bleomycin-treated animals that was completely blocked by R36 in vitro [1].
Proteins associated with cytoplasmic membrane functions (ACTN4, hyaluronan mediated motility receptor (RHAMM), VLDLR, GRK3) and/or endocytosis (DNM2) were also seen [2].

Associations of Hmmr with chemical compounds

Surface biotin labeling of cells isolated by lavage confirmed increased surface expression of a 70-kD RHAMM after lung injury, and in situ hybridization demonstrated increased RHAMM mRNA in macrophages responding to injury [1].

References

Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury. Zaman, A., Cui, Z., Foley, J.P., Zhao, H., Grimm, P.C., Delisser, H.M., Savani, R.C. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib, K., Norman, J.T., Fine, L.G., Brown, L.R., Godovac-Zimmermann, J. Proteomics (2005) [Pubmed]

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