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Gene Review

NEGR1  -  neuronal growth regulator 1

Homo sapiens

Synonyms: DMML2433, IGLON4, IgLON family member 4, KILON, MGC46680, ...
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High impact information on NEGR1

  • Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family [1].
  • Kilon immunostaining was observed in the cerebral cortex and hippocampus, in which the strongly stained puncta were observed on dendrites and soma of pyramidal neurons [1].
  • The expression levels of individual IgLONs were correlated, the most significant finding being a positive correlation between LSAMP and NEGR1 [2].
  • The family consists of LAMP, OBCAM, neurotrimin/CEPU-1 and neurotractin/kilon [3].
  • This paper forms part of a Doctorate Thesis, currently being completed at the Allergy and Immunology Section of the Ntra [4].

Analytical, diagnostic and therapeutic context of NEGR1

  • Kilon-specific monoclonal antibodies were produced, and Western blotting analysis showed that expression of Kilon is restricted to brain, and Kilon has an apparent molecular mass of 46 kDa in SDS-polyacrylamide gel electrophoresis in its expressed form [1].


  1. Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. Funatsu, N., Miyata, S., Kumanogoh, H., Shigeta, M., Hamada, K., Endo, Y., Sokawa, Y., Maekawa, S. J. Biol. Chem. (1999) [Pubmed]
  2. The IgLON family in epithelial ovarian cancer: expression profiles and clinicopathologic correlates. Ntougkos, E., Rush, R., Scott, D., Frankenberg, T., Gabra, H., Smyth, J.F., Sellar, G.C. Clin. Cancer Res. (2005) [Pubmed]
  3. Promotion of neuronal cell adhesion by members of the IgLON family occurs in the absence of either support or modification of neurite outgrowth. McNamee, C.J., Reed, J.E., Howard, M.R., Lodge, A.P., Moss, D.J. J. Neurochem. (2002) [Pubmed]
  4. Historical background of aeropalynology in the Canary Islands. García Cobaleda, I., De la Torre Morin, F., Hardisson de la Torre, A. Allergologia et immunopathologia. (1996) [Pubmed]
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