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Gene Review

LSAMP  -  limbic system-associated membrane protein

Homo sapiens

Synonyms: IGLON3, IgLON family member 3, LAMP, Limbic system-associated membrane protein
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Disease relevance of LSAMP


Psychiatry related information on LSAMP

  • This issue of The Lamp acknowledges the important contribution of mental health nurses to the profession of nursing [4].

High impact information on LSAMP


Biological context of LSAMP

  • Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation [1].
  • While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs [1].
  • The epidemiology of burns, challenges faced in their management and effective strategies specific to Sri Lanka, such as the Safe Bottle Lamp campaign, are highlighted in this paper [9].

Anatomical context of LSAMP


Associations of LSAMP with chemical compounds

  • Aerobic Oxidation of Benzyl- and Allylic Alcohols under Visible Light Irradiation of a Fluorescent Lamp in the Presence of Catalytic Iodine [13].

Analytical, diagnostic and therapeutic context of LSAMP


  1. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Chen, J., Lui, W.O., Vos, M.D., Clark, G.J., Takahashi, M., Schoumans, J., Khoo, S.K., Petillo, D., Lavery, T., Sugimura, J., Astuti, D., Zhang, C., Kagawa, S., Maher, E.R., Larsson, C., Alberts, A.S., Kanayama, H.O., Teh, B.T. Cancer Cell (2003) [Pubmed]
  2. Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours. Reed, J.E., Dunn, J.R., du Plessis, D.G., Shaw, E.J., Reeves, P., Gee, A.L., Warnke, P.C., Sellar, G.C., Moss, D.J., Walker, C. Neuropathol. Appl. Neurobiol. (2007) [Pubmed]
  3. Rigid gas permeable contact lens correction of aphakia following congenital cataract removal during infancy. Amos, C.F., Lambert, S.R., Ward, M.A. Journal of pediatric ophthalmology and strabismus. (1992) [Pubmed]
  4. Stories from mental health. Stewart, L., Treloar, A., Lyons, J. The Lamp. (1996) [Pubmed]
  5. Chemical anatomy of primate basal ganglia. Parent, A., Côté, P.Y., Lavoie, B. Prog. Neurobiol. (1995) [Pubmed]
  6. The IgLON family in epithelial ovarian cancer: expression profiles and clinicopathologic correlates. Ntougkos, E., Rush, R., Scott, D., Frankenberg, T., Gabra, H., Smyth, J.F., Sellar, G.C. Clin. Cancer Res. (2005) [Pubmed]
  7. Limbic system-associated membrane protein (LAMP) in primate amygdala and hippocampus. Côté, P.Y., Levitt, P., Parent, A. Hippocampus. (1996) [Pubmed]
  8. Distribution of the limbic system-associated membrane protein (LAMP) in pigeon forebrain and midbrain. Yamamoto, K., Reiner, A. J. Comp. Neurol. (2005) [Pubmed]
  9. An insight into burns in a developing country: A Sri Lankan experience. Lau, Y.S. Public health. (2006) [Pubmed]
  10. cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP). Pimenta, A.F., Fischer, I., Levitt, P. Gene (1996) [Pubmed]
  11. Signaling pathways that regulate specification of neurons in developing cerebral cortex. Levitt, P., Eagleson, K.L., Chan, A.V., Ferri, R.T., Lillien, L. Dev. Neurosci. (1997) [Pubmed]
  12. Sexual abuse of children. The detection of semen on skin. Gabby, T., Winkleby, M.A., Boyce, W.T., Fisher, D.L., Lancaster, A., Sensabaugh, G.F. Am. J. Dis. Child. (1992) [Pubmed]
  13. Aerobic Oxidation of Benzyl- and Allylic Alcohols under Visible Light Irradiation of a Fluorescent Lamp in the Presence of Catalytic Iodine. Nakayama, H., Itoh, A. Chem. Pharm. Bull. (2006) [Pubmed]
  14. Hyperbaric oxygenation and blood lactate clearance: study in sixty male naval cadets. Sueblinvong, T., Egtasaeng, N., Sanguangrangsirikul, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2004) [Pubmed]
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