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MeSH Review

Allergy and Immunology

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Disease relevance of Allergy and Immunology


High impact information on Allergy and Immunology

  • The immunology of the 65 kd heat shock protein (hsp65) is paradoxical [6].
  • Stress-induced immunological reactions to exercise have stimulated much research into stress immunology and neuroimmunology [7].
  • This physiological mechanism, termed the 'cholinergic anti-inflammatory pathway' has major implications in immunology and in therapeutics; however, the identity of the essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signals was previously unknown [8].
  • Immunology: Fast and feel good [9]?
  • Immunology: Oxygen and the inflammatory cell [10].

Chemical compound and disease context of Allergy and Immunology


Biological context of Allergy and Immunology

  • Recent advances in tumor immunology suggest that the expression of the histocompatibility antigens, encoded by the major histocompatibility complex, is important in controlling the metastatic growth of certain murine tumors [16].
  • The topics included: the interactions between immunogenic peptides, class I MHC molecules and T cell receptors; initiation, maintenance, and breakdown of self-tolerance in B lymphocytes; inflammatory disease in HLA-B27 transgenic rats; properties and functions of interleukin-10; and transforming growth factor-beta in reproductive immunology [17].
  • Thus, the low titer, low affinity naturally occurring antibody became functionally relevant by preferred generation of C3b-IgG complexes that can nucleate alternative complement pathway C3 convertases and represent the most effective opsonins (Fries, L. F., Siwik, S. A., Malbran, A., and Frank, M. M. (1987) Immunology 62, 45-51) [18].
  • The extent to which naive CD8(+) CTLs (T(CD8)(+)) are primed by APCs presenting endogenous Ags (direct priming) or Ags acquired from other infected cells (cross-priming) is a critical topic in basic and applied immunology [19].
  • A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis [20].

Anatomical context of Allergy and Immunology


Associations of Allergy and Immunology with chemical compounds


Gene context of Allergy and Immunology

  • Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology [31].
  • The pituitary secretory proteins growth hormone (GH) and prolactin (PRL) do not, as yet, have major roles in haematology or immunology [32].
  • In this review, we discuss how basic and clinical immunology have combined to provide major insights into the function of CD40 in T-B cell collaboration [33].
  • Of all the lymphokine-receptor systems in immunology, perhaps most is known about the structure, function, and binding properties of IL-2 and its cognate receptor [34].
  • We here review the potential role of HLA-G in RCC immunology, the HLA-G expression pattern and its functional consequences on immune responses [35].

Analytical, diagnostic and therapeutic context of Allergy and Immunology


  1. HMGB1 in the immunology of sepsis (not septic shock) and arthritis. Czura, C.J., Yang, H., Amella, C.A., Tracey, K.J. Adv. Immunol. (2004) [Pubmed]
  2. Pitfalls in the care of patients with tuberculosis. Common errors and their association with the acquisition of drug resistance. Mahmoudi, A., Iseman, M.D. JAMA (1993) [Pubmed]
  3. Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides. Lanchbury, J.S., Pitzalis, C. Curr. Opin. Immunol. (1993) [Pubmed]
  4. Immunologic abnormalities in an animal model of chronic hypoplastic marrow failure induced by busulfan. Pugsley, C.A., Forbes, I.J., Morley, A.A. Blood (1978) [Pubmed]
  5. Pathogenicity of T cells responsive to diverse cryptic epitopes of myelin basic protein in the Lewis rat. Mor, F., Cohen, I.R. J. Immunol. (1995) [Pubmed]
  6. Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. Cohen, I.R. Annu. Rev. Immunol. (1991) [Pubmed]
  7. Exercise and the immune system: regulation, integration, and adaptation. Pedersen, B.K., Hoffman-Goetz, L. Physiol. Rev. (2000) [Pubmed]
  8. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Wang, H., Yu, M., Ochani, M., Amella, C.A., Tanovic, M., Susarla, S., Li, J.H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C.J., Tracey, K.J. Nature (2003) [Pubmed]
  9. Immunology: Fast and feel good? Kuchroo, V.K., Nicholson, L.B. Nature (2003) [Pubmed]
  10. Immunology: Oxygen and the inflammatory cell. Nathan, C. Nature (2003) [Pubmed]
  11. Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin. Warrell, D.A., Perine, P.L., Krause, D.W., Bing, D.H., MacDougal, S.J. J. Infect. Dis. (1983) [Pubmed]
  12. Reduction of proteinuria with mycophenolate mofetil in predominantly membranous lupus nephropathy. Karim, M.Y., Pisoni, C.N., Ferro, L., Tungekar, M.F., Abbs, I.C., D'Cruz, D.P., Khamashta, M.A., Hughes, G.R. Rheumatology (Oxford, England) (2005) [Pubmed]
  13. Acetylcholine receptor antibodies in the diagnosis of human and experimental myasthenia gravis. Heilbronn, E., Lefvert, A.K., Stålberg, E. Muscle Nerve (1978) [Pubmed]
  14. Brain tumors in pregnancy. Simon, R.H. Seminars in neurology. (1988) [Pubmed]
  15. Los alamos hepatitis C immunology database. Yusim, K., Richardson, R., Tao, N., Dalwani, A., Agrawal, A., Szinger, J., Funkhouser, R., Korber, B., Kuiken, C. Appl. Bioinformatics (2005) [Pubmed]
  16. Histocompatibility antigens on murine tumors. Goodenow, R.S., Vogel, J.M., Linsk, R.L. Science (1985) [Pubmed]
  17. Contemporary topics in immunology: approaches to immunotherapy emerging from basic research. Albright, J.F., Oppenheim, J.J. FASEB J. (1992) [Pubmed]
  18. Preferential formation of C3b-IgG complexes in vitro and in vivo from nascent C3b and naturally occurring anti-band 3 antibodies. Lutz, H.U., Stammler, P., Fasler, S. J. Biol. Chem. (1993) [Pubmed]
  19. Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells. Basta, S., Chen, W., Bennink, J.R., Yewdell, J.W. J. Immunol. (2002) [Pubmed]
  20. A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis. Wallis, R.S., Kyambadde, P., Johnson, J.L., Horter, L., Kittle, R., Pohle, M., Ducar, C., Millard, M., Mayanja-Kizza, H., Whalen, C., Okwera, A. AIDS (2004) [Pubmed]
  21. Peptide selection by MHC-encoded TAP transporters. Momburg, F., Neefjes, J.J., Hämmerling, G.J. Curr. Opin. Immunol. (1994) [Pubmed]
  22. Osteoclast precursors, RANKL/RANK, and immunology. Xing, L., Schwarz, E.M., Boyce, B.F. Immunol. Rev. (2005) [Pubmed]
  23. Plagiarism of the host immune system: lessons about chemokine immunology from viruses. Wells, T.N., Schwartz, T.W. Curr. Opin. Biotechnol. (1997) [Pubmed]
  24. Interaction of the human autoantigen p150 with splicing snRNPs. Blencowe, B.J., Carmo-Fonseca, M., Behrens, S.E., Lührmann, R., Lamond, A.I. J. Cell. Sci. (1993) [Pubmed]
  25. Expression profiling in transformed human B cells: influence of Btk mutations and comparison to B cell lymphomas using filter and oligonucleotide arrays. Islam, T.C., Lindvall, J., Wennborg, A., Brandén, L.J., Rabbani, H., Smith, C.I. Eur. J. Immunol. (2002) [Pubmed]
  26. Functions of glutathione and glutathione disulfide in immunology and immunopathology. Dröge, W., Schulze-Osthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H.P., Roth, S., Gmünder, H. FASEB J. (1994) [Pubmed]
  27. Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus. Jouvin-Marche, E., Attuil-Audenis, V., Aude-Garcia, C., Rachidi, W., Zabel, M., Podevin-Dimster, V., Siret, C., Huber, C., Martinic, M., Riondel, J., Villiers, C.L., Favier, A., Naquet, P., Cesbron, J.Y., Marche, P.N. J. Immunol. (2006) [Pubmed]
  28. Properties of purified carnitine acyltransferases of mouse liver peroxisomes. Farrell, S.O., Fiol, C.J., Reddy, J.K., Bieber, L.L. J. Biol. Chem. (1984) [Pubmed]
  29. Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes. Peakman, M., Tree, T.I., Endl, J., van Endert, P., Atkinson, M.A., Roep, B.O. Diabetes (2001) [Pubmed]
  30. Kaposi's sarcoma in HIV infection treated with vincristine and bleomycin. Gompels, M.M., Hill, A., Jenkins, P., Peters, B., Tomlinson, D., Harris, J.R., Stewart, S., Pinching, A.J., Munro, A.J. AIDS (1992) [Pubmed]
  31. Biology of the interleukin-2 receptor. Nelson, B.H., Willerford, D.M. Adv. Immunol. (1998) [Pubmed]
  32. Growth hormone and prolactin are paracrine growth and differentiation factors in the haemopoietic system. Hooghe, R., Delhase, M., Vergani, P., Malur, A., Hooghe-Peters, E.L. Immunol. Today (1993) [Pubmed]
  33. CD40 ligand and its role in X-linked hyper-IgM syndrome. Callard, R.E., Armitage, R.J., Fanslow, W.C., Spriggs, M.K. Immunol. Today (1993) [Pubmed]
  34. Interleukin-2 and the IL-2 receptor: new insights into structure and function. Kuziel, W.A., Greene, W.C. J. Invest. Dermatol. (1990) [Pubmed]
  35. The role of HLA-G for protection of human renal cell-carcinoma cells from immune-mediated lysis: implications for immunotherapies. Bukur, J., Seliger, B. Semin. Cancer Biol. (2003) [Pubmed]
  36. Chemokine receptor polymorphism in transplantation immunology: no longer just important in AIDS. Strieter, R.M., Belperio, J.A. Lancet (2001) [Pubmed]
  37. Seven years of remission in a type I diabetic patient. Koivisto, V.A., Leirisalo-Repo, M., Ebeling, P., Tuominen, J.A., Knip, M., Turunen, U., Mandrup-Poulsen, T., Pelkonen, R. Diabetes Care (1993) [Pubmed]
  38. Allogeneic bronchoalveolar lavage cells induce the histology and immunology of lung allograft rejection in recipient murine lungs: role of intercellular adhesion molecule-1 on donor cells. Wilkes, D.S., Bowman, D., Cummings, O.W., Heidler, K.M. Transplantation (1999) [Pubmed]
  39. A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3). Wallis, R.S., Kalayjian, R., Jacobson, J.M., Fox, L., Purdue, L., Shikuma, C.M., Arakaki, R., Snyder, S., Coombs, R.W., Bosch, R.J., Spritzler, J., Chernoff, M., Aga, E., Myers, L., Schock, B., Lederman, M.M. J. Acquir. Immune Defic. Syndr. (2003) [Pubmed]
  40. Relationship of hepatocyte growth factor in human umbilical vein serum to gestational age in normal pregnancies. Khan, N., Couper, J., Goldsworthy, W., Aldis, J., McPhee, A., Couper, R. Pediatr. Res. (1996) [Pubmed]
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