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Gene Review

FBXL2  -  F-box and leucine-rich repeat protein 2

Homo sapiens

Synonyms: F-box protein FBL2/FBL3, F-box/LRR-repeat protein 2, FBL2, FBL3
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Disease relevance of FBXL2


High impact information on FBXL2

  • Five of them (FBL3 to FBL7) share structural similarities with Skp2 and contain C-terminal leucine-rich repeats [4].
  • Here we report the cloning, analysis of genomic organization and characterization of a novel gene product related to Skp2 named FBL2 [5].
  • The human FBL2 gene was found to be a highly interrupted gene of at least 126.6 kb located on chromosome 17 in close proximity to the TRAP220 gene in a head-to-tail orientation [5].
  • In these cured mice, FBL-3-specific CD4-8+ CTL cells were found to be generated in PEC, spleen and lymph node cells by either in vivo or in vitro re-stimulation with FBL-3 cells, but lymphokine-activated killer cells never developed [2].

Anatomical context of FBXL2


Analytical, diagnostic and therapeutic context of FBXL2

  • The successful adoptive immunotherapy of the syngeneic Friend virus-induced murine leukemia FBL-3 was mediated by a proliferative MHC-restricted, tumor-specific CTL clone in combination with recombinant human IL 2 [6].


  1. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Wang, C., Gale, M., Keller, B.C., Huang, H., Brown, M.S., Goldstein, J.L., Ye, J. Mol. Cell (2005) [Pubmed]
  2. The in vivo anti-tumor effect of human recombinant interleukin-6. Kitahara, M., Kishimoto, S., Hirano, T., Kishimoto, T., Okada, M. Jpn. J. Cancer Res. (1990) [Pubmed]
  3. Immunotherapy of cancer by systemic administration of lymphoid cells plus interleukin-2. Rosenberg, S.A. Journal of biological response modifiers. (1984) [Pubmed]
  4. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Ilyin, G.P., Rialland, M., Pigeon, C., Guguen-Guillouzo, C. Genomics (2000) [Pubmed]
  5. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. Ilyin, G.P., Rialland, M., Glaise, D., Guguen-Guillouzo, C. FEBS Lett. (1999) [Pubmed]
  6. Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression. Matis, L.A., Shu, S., Groves, E.S., Zinn, S., Chou, T., Kruisbeek, A.M., Rosenstein, M., Rosenberg, S.A. J. Immunol. (1986) [Pubmed]
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